Jiangnan University

Chunlei Tang

Yongquan Chen

Shenglong Zhu

Ninghan Feng

Xiaoying Wang

Zhen Chen

Guozhen Cui

Peng Zhang

Hongyan Qu

Xin Ma

Kai Shan

Yanfei Cai

Lengyun Wei

Dongxu He

Guosheng Wu

The disclosure discloses a fatty acid synthase inhibitor and application thereof and belongs to the technical field of medical biology. The fatty acid synthase inhibitor of the disclosure can significantly inhibit the activity of fatty acid synthase without affecting normal expression, and adjust the ratio of fatty acids in cells. The fatty acid synthase inhibitor of the disclosure has a good tumor proliferation inhibitory effect, can arrest the growth cycle of tumor cells in the interphase, prevent tumor cell division, inhibit tumor cell proliferation, promote tumor cell apoptosis and exert a tumor treatment effect, can be used to treat tumors and metabolism related diseases, and has an important clinical application prospect.

Fatty acid synthase inhibitor and application thereof

The applicant provides a compound for enhancing the space coupling degree of an endothelial cell ion channel complex TRPV4-KCa2.3 and anti-hypertension applications thereof. By finding the structural domains of the interacting sites of the endothelial cell ion channel complex TRPV4-KCa2.3, a compound with specificity which can act at the two interacting sites is prepared in the present invention. It is found that the compound can enhance the space coupling degree of the TRPV4-KCa2.3 complex and has great significance for the research and development of anti-hypertension drugs.

Compound for enhancing the coupling degree of complex TRPV4-KCa2.3 and anti-hypertension applications thereof

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Wuxi, China

Chunlei Tang