Chinese Pla General Hospital

Shijiazhuang Sagacity New Drug Development Company, Ltd.

Chunlei Liu

Xin Li

Wei Li

Lili Wang

Song Li

Wu Zhong

Junhai Xiao

Long Long

Kunlun He

Guoliang Hu

Jie Wang

Zhibing Zheng

Juan Liu

Jie Tang

Yunfu Luo

Chen Bo Li

Hua Chen

Wenyuan Qian

Chundao Yang

Chen Li

Ruijun Li

Jie Bai

Maoyi Lei

Junmiao Li

Guanghai Xu

Zeyu Zhang

Kunluu He

Ruijin Li

Xiaojian Gao

Yiwei Wang

The present disclosure provides application of a compound in conformity with a general formula I and an isomer or pharmaceutically acceptable salt thereof to preparation of a medicinal composition for treating or preventing a high altitude disease. The high altitude disease is selected from an acute high altitude disease and a chronic high altitude disease generated in a high altitude environment with an altitude of 2,000 m or above.

Medical application of pyrimidine sulfonamides derivatives

The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate of the compound, and to a composition comprising the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents. The present invention also relates to use of the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, and for preventing or treating a disease or disorder associated with cardiomyocyte apoptosis. 

Acrylamide compounds and use thereof for inhibiting apoptosis

A compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, is provided. Also, a composition containing a compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents, is provided. Further, use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof for anti-apoptosis is provided, preventing or treating a disease or disorder associated with apoptosis; especially for protecting cardiomyocyte, preventing or treating a disease or disorder associated with cardiomyocyte apoptosis. 

Urea compounds and use thereof for inhibiting apoptosis

The present invention relates to an acrylamide compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, to a composition comprising the compound or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent, and to a use of the compound or the composition for prophylaxis and/or treatment of a disease or disorder associated with cardiomyocyte apoptosis.

(2E)-3-phenyl-N-[2,2,2-Trifluoro-1-[[8-quinolineamino)thiomethyl]amino]ethyl]-2-acrylamide and pharmaceutical uses thereof

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Beijing, China

Chunlei Liu