Other

Chongqing Fagen Biomedical Inc.

Lunan Pharmaceutical Group Corporation

Shandong New Time Pharmaceutical Co., Ltd.

Chunlan Hu

Kai Fan

Chun Zhang

Xiang Mei

Xuefeng Ma

Li Ping Yang

Hua Luo

Provided are a PEGylated analogue protein of canine urate oxidase, preparation method and use thereof. The analogue protein of canine urate oxidase is a canine urate oxidase, or a chimeric protein comprising part of the amino acid sequence of a canine urate oxidase and part of the amino acid sequence of a human urate oxidase, or a mutant protein thereof. The PEGylated analogue protein of canine urate oxidase and pharmaceutical compositions thereof according to the present invention can be used for the prevention and/or treatment of hyperuricemia and chronic gout.

Pegylated analogue protein or canine urate oxidase, preparation method and use thereof

The present invention provides a humanized recombinant uricase and mutants thereof, wherein the humanized recombinant uricase is a chimeric protein which comprises amino acids of non-human mammal uricase and amino acids of human uricase. The humanized recombinant unease and mutants thereof have reduced immunogenicity in human, and can be used for the treatment of hyperuricemia and gout.

Humanized recombinant uricase and mutants thereof

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Chongqing, China

Chunlan Hu