Vertex Pharmaceuticals, Inc.

Chunhui Xie

George Harb

Christopher D Thanos

Evrett Thompson

Rebecca Chinn

Aleksander Szymaniak

Suyash Raj

Bryce W Carey

Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.

Differentiation of pancreatic endocrine cells

Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.

Stem cell derived pancreatic islet differentiation

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Belmont, MA, United States of America

Chunhui Xie