Bayer Healthcare LLC

Bayer Pharmaceuticals Corporation

Chunguang Wang

Dhanapalan Nagarathnam

Lei Zhang

Brian Richard Bear

Alexander Hillisch

Uday R Khire

Olaf Weber

Martin F Hentemann

Yuanwei Chen

Julie A Dixon

Ming Wang

Stephen Boyer

Jianqing Chen

Ann-Marie Bullion

Davoud Asgari

Michael Brands

Donald Bierer

Lin Yi

Wenlang Fu

Jianxing Shao

Barry Hart

Mark Lynch

Xiao-Gao Liu

Jacques P Dumas

Achim Feurer

Manoj Patel

Holia Hatoum-Mokdad

Samir Bennabi

Lei Wang

Hans Pluempe

Donald Bankston

Dhanaphalan Nagarathnam

Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R, G, G', and G&#x2033; represent substituent groups and Rrepresents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.

Pyrimidine derivatives for treatment of hyperproliferative disorders

Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors

A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.

Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof

Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R, G, G', and G&#x2033; represent substituent groups and Rrepresents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed. 

Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

Rho-kinase inhibitors

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Hamden, CT, United States of America

Chunguang Wang