National Health Research Institutes

Other

Tsinghua University

National Chung Cheng University

Materials Analysis Technology (US) Corp.

Materials Analysis Technology Inc.

Chung-Shi Yang

Leu-Wei Lo

Yeu-Kuang Hwu

Jen-Kun Chen

Shu-Yi Lin

Lin-Ai Tai

Yi-Ting Wu

Yu-Chao Wang

Chia-Hung Lee

Wei-Neng Liao

Chi-Jen Liu

Gwo-Bin Lee

Chih-hsun Chu

Lai-Kwan Chau

Yi-Hung Lin

Chung-Yuan Mou

Shu-Hui Chen

Hong-Ming Lin

Yong-fen Hsieh

Cheng-Liang Wang

Yong-Chien Ling

Fong-In Chou

Wei-Zhe Chang

Wei-Te Wu

Fu-Der Mai

Jinn-Jer Peir

Yu-feng Ko

Pradeep Sharma

Chang-Hai Wang

Yu-Ching Chen

Mei-Hui Shih

Guan-Ruey Huang

Wan-Chou Sung

Feng-Yin Li

Bega Liu

Yu-Jing Wang

Jung-Ho Je

Chi-Hsiung Chen

Mo-Hsiung Yang

Chih-Hui Liu

Mei-Ya Wang

Giorgio Margartondo

Fong-Sian Lin

Shih-Hsun Cheng

Shin-Hsun Cheng

Chih-Hsun Chu

Yu-Feng Ko

Hsiao-Chun Ting

Particles and manufacturing methods thereof are provided. The manufacturing method of the particle includes providing a precursor solution containing a precursor dissolved in a solution, and irradiating the precursor solution with a high energy and high flux radiation beam to convert the precursor to nano-particles. Particles with desired dispersion, shape, and size are manufactured without adding a stabilizer or surfactant to the precursor solution.

Particles and manufacturing methods thereof

A method for prevention and/or treatment of steatorrhea in a subject is disclosed. The method comprises administering to the subject a composition comprising mesoporous silica nanoparticles (MSNs) in an amount effective for prevention and/or treatment of steatorrhea in the subject

Mesoporous silica nanoparticles for oil absorption

A specimen kit having a tiny chamber is disclosed for a specimen preparation for TEM. The space height of the chamber is far smaller than dimensions of blood cells and therefore is adapted to sort nanoparticles from the blood cells. The specimen prepared under this invention is suitable for TEM observation over a true distribution status of nanoparticles in blood. The extremely tiny space height in Z direction eliminates the possibility of aggregation of the nanoparticles and/or agglomeration in Z direction during drying; therefore, a specimen prepared under this invention is suitable for TEM observation over the dispersion and/or agglomeration of nanoparticles in a blood.

Specimen preparation for transmission electron microscopy

A method of synthesizing ligand-conjugated gold nanoparticles (AuNPs) is disclosed. The method comprises: a) providing an amine-modified silica particle; b) providing a solution comprising Auions; c) suspending the amine-modified silica particle in the solution comprising Auions; d) allowing the Auions to be adsorbed and/or immobilized onto the surface of the amine-modified silica particle; e) exposing the Auions immobilized onto the surface of the amine-modified silica particle to radiation to obtain bare gold nanoparticles (AuNPs) adsorbed and/or immobilized onto the surface of the amine-modified silica particle, wherein the bare AuNPs are without organic surface modifications; and f) reacting a ligand with the bare AuNPs adsorbed and/or immobilized onto the surface of the amine-modified SiNP and thereby obtain ligand-conjugated gold nanoparticles (AuNPs).

Solid phase gold nanoparticle synthesis

A method of synthesizing a random copolymer of polyethyleneimine and polyethylene glycol, comprising exposing ethanolamine in a solution to electromagnetic radiation for a sufficient time to polymerize the ethanolamine (OHCHCHNH) and thereby resulting in formation of the randome copolymer comprising polyethyleneimine and poly(ethylene glycol), wherein the polyethyleneimine comprises ethyleneimine (&#x2014;CHCHNH&#x2014;) unit and the polyethylene glycol comprises ethylene glycol (&#x2014;CHCHO&#x2014;) unit, and the polyethylenimine of the random copolymer has a substantially linear backbone.

Single monomer derived linear-like copolymer comprising polyethylenimine and poly(ethylene glycol) for nucleic acid delivery

A controlled release multidrug formulation for improving locomotor recovery after spinal cord injury comprising: (a) a first composition comprising a first bioactive agent, encapsulated within a first polymeric particle; (b) a second composition comprising a second bioactive agent, encapsulated within a second polymeric particle, wherein the second polymeric particle is encapsulated within the first polymeric particle; and (c) a third composition comprising a third bioactive agent, encapsulated within either the first or the second polymeric particle, wherein the second composition is released subsequently to the release of the first composition, and wherein the first bioactive agent is a neurotrophic factor, the second bioactive agent is a collagen synthesis inhibitor, and the third bioactive agent is selected from the group consisting of cyclic AMP (cAMP), an adenylate cyclase activator and a Rho inhibitor.

Controlled release multidrug formulations for spinal cord injury

Methods of preparing a composition comprising non-ionic, radioactive gold nanoparticles (R-GNPs) are disclosed. The method comprises: a) providing an aqueous composition comprising gold (Au-197) ions in the absence of a template; and b) exposing the aqueous composition in the absence of the template to neutron irradiation to generate the composition comprising the non-ionic R-GNPs. Alternatively, the method comprises: a) providing an aqueous composition comprising gold (Au-197) nanoparticles (GNPs) in the absence of a template; and b) exposing the aqueous composition comprising the GNPs in the absence of the template to neutron irradiation and thereby generating the composition comprising the non-ionic R-GNPs. Compositions that comprises mesoporous silica nanoparticles (MSNs) and non-ionic R-GNPs encapsulated within pores and/or channels and further anchored to the surfaces of the MSNs, and methods of making the same are also disclosed.

Radioactive gold nanoparticles and methods of making and using them

A charged mesoporous silica nanoparticle (MSN)-based drug delivery system for controlled release and enhanced bioavailability is disclosed. The system comprises a positively charged MSN, which has a silica matrix and an array of pores and/or nanochannels in the matrix. The entire substance of the matrix, all the surfaces and the pores and/or nanochannels comprise a plurality of silanol (Si&#x2014;OH) and quaternary ammonium functional groups. The bioavailability of a negatively charged bioactive compound can be increased by loading it into the pores and/or nanochannels. The silanol (Si&#x2014;OH) functional groups on the surfaces lining the walls of the pores and/or nanochannels are free to deprotonate in a fluid having pH above the pI of the positively charged MSN and lead to a sustained release of the negatively charged drug from the pores and/or nanochannels, and thereby enhance the bioavailability of the drug.

Charged mesoporous silica nanoparticle-based drug delivery system for controlled release and enhanced bioavailability

A blood flow control system, tension adjustable instrument and a method are disclosed. The blood flow control system comprises a detecting unit, a computing and a tension adjustable instrument. The detecting unit real-time monitors the biomolecular response condition of a living organ, and the computing unit dynamically controls the tension adjustable instrument to adjust the tension of the blood vessel based on the detecting result. Therefore the blood flow control system can maintain the biomolecular response condition over a predetermined range to reduce the risk of the liver organ being damaged and augment the curability.

Blood flow control system, tension adjustable instrument and method thereof

A quantum dot (QD) conjugate comprises a QD and a ligand conjugated with the QD, in which the ligand has at least one thiol and at least one other functional group. The QD conjugate may further comprise a bioactive agent covalently coupled to the ligand to form a bioactive agent-tagged QD conjugate. A method for preparing a QD conjugate comprises the steps of: (1) providing a solution comprising a QD encapsulated within a dendrimer; (2) adding into the solution a ligand; and (3) allowing an exchange between the ligand and the dendrimer for the QD to obtain a ligand-QD conjugate, in which the ligand is covalently conjugated to the surface of the QD. The method may further comprise the step of coupling the ligand-QD conjugate to a bioactive agent to obtain a bioactive agent-tagged ligand-QD conjugate.

Method for making a ligand-quantum dot conjugate

The present invention discloses a fiber-optic localized plasmon resonance (FO-LPR) sensing device and a sensing system thereof, the FO-LPR sensing system includes a light source, a FO-LPR sensing device and a detector, and the light source provides a light beam entered into the FO-LPR sensing device, and the detector generates a detected signal according to an emergent light from the FO-LPR sensing device. The FO-LPR sensing device includes an optical fiber, a noble metal nanoparticle layer and a filter film layer. The filter film layer is having a porous material, and the porous material comes with a pore diameter or a property selected according to a feature of a sample, while an interfering substance in the sample is isolated.

Fiber-optic localized plasmon resonance sensing device and system thereof

Methods and compositions for enhancing transdermal delivery of a bioactive agent. The method contains the step of applying to a skin tissue an effective amount of a composition comprising: (a) a drug vehicle; (b) a bioactive agent encapsulated within the drug vehicle; (c) a plurality of proteolytic enzyme molecules conjugated onto the surface of the drug vehicle; and (d) a pharmaceutically acceptable carrier, for a period of time effective to deliver the bioactive agent across the skin tissue at a desired dosage.

Methods and compostions for enhancing transdermal drug delivery

A nano-particle containing apparatus, a nano-particle detection system and a method are disclosed. The nano-particle containing apparatus includes a casing, an air extracting device, a pressure device and a measuring instrument. The casing has a containing space for disposing a plurality of nano-particles. An internal wall surface of the casing has active self-cleaning function. The pressure control device controls the pressure status of the containing space. The active self-clean function is that nano-particles adhered to the internal surface wall are removed into the containing space. The nano-particles then are pumped by the air extracting device from the containing space. The measuring instrument then detects the status of an object affected by the nano-particles after the object is delivered into the containing space.

Nano-particle containing apparatus, nano-particle detection system and method thereof

The present invention relates to a sample analysis system with chip-based electrophoresis device, particularly, the chip electrophoresis is connected to the dynamic flow-based auto-sampling device to introduce the sample into the chip-based electrophoresis device. By utilizing the derivatization biochemistry method to have a surface modification on the sample loading channel, it prevents the sample from being adhered to the wall of the sample loading channel, and hence increases the sample loading rate, reduces cross-contamination of samples and performs specific bio-reaction by using the immobilization of matter including antigen, antibody, protein, or enzyme. This invention makes use of the continuous split flow and electric voltage control to work with the detecting unit, signal collecting unit, and signal processing unit so that the sample undergoes a timely, fast, continuous analysis without having interference from the sample of other time.

Sample analysis system with chip-based electrophoresis device

Growing community of inventors

Taichung, Taiwan

Chung-Shi Yang