Lg Chemical Ltd.

Chung Ryeol Kim

Jong Sung Koh

Ho Il Choi

Sung Chun Kim

Nakyen Choy

Heungsik Yoon

Young Chan Son

Chang Sun Lee

Chi Hyo Park

Sang Soo Kim

Won Hee Jung

Wonhee Jung

Kwang-Yul Moon

Kwang Yul Moon

The present invention relates to a novel compound of formula (I) and pharmaceutically acceptable salts, hydrates and solvates thereof which is an irreversible HIV protease inhibitor; a process for the preparation thereof; and a pharmaceutical composition containing the compound as an active ingredient which is useful for treating or preventing diseases caused by HIV infection. ##STR1##

Irreversible HIV protease inhibitor having an anti-aids activity and

Novel cis-epoxide compounds of formula (I) are useful for treating or preventing diseases caused by HIV infection: ##STR1## wherein A, B, R.sub.1 to R.sub.4 and n have the same meanings as defined in the specification. The novel HIV protease inhibitor of the formula (I) has a specific structure to form a stable bonding with the enzyme active site, which entails a highly enhanced irreversible inhibition against HIV protease.

Irreversible HIV protease inhibitors, intermediates, compositions and

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Daejeon, South Korea

Chung Ryeol Kim