Abgenomics Cooperatief U.a.

Boehringer Mannheim Gmbh

Protein Design Labs, Inc.

Chung Nan Chang

Rong-Hwa Lin

Chiu-Chen Huang

Pei-Jiun Chen

Nicholas F Landolfi

Ulrich Martin

Ronghwa Lin

Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of inducing death of an activated T-cell and of modulating a T cell-mediated immune response in a subject.

Methods of treating with anti-PSGL-1 antibodies

Methods of treating GVHD and transplant rejection with anti-PSGL-1 antibodies

Cell death-inducing epitopes and polypeptides containing same. Also disclosed are compounds for inducing death of activated T-cells, a method of producing antibodies to the epitopes, a method of identifying compounds that bind to the epitopes, a method of inducing death of activated T-cells, and pharmaceutical compositions containing the compounds.

T-cell death-inducing epitopes

Anti-PSGL-1 antibodies and methods of inducing cell death of an activated T cell

Anti-PSGL-1 antibodies

Multimeric compounds that bind to P-Selectin Glycoprotein 1 (PSGL-1) on the surface of T cells or natural killer (NK) cells can be used to induce T cell or NK cell depletion and/or to induce T cell or NK cell apoptosis. The multimeric compounds and methods of the invention can be used to control unwanted T cell- or NK cell-mediated immune responses in conditions such as inflammatory diseases, autoimmune diseases, transplant rejection, and allergic diseases.

Methods of reducing T cell-mediated immune responses with multimeric P-selectin and/or E-selectin compounds

Methods of inducing cell death of an activated T cell with anti-PSGL-1 antibodies

The invention relates to monoclonal antibodies, humanized monoclonal antibodies and functional derivatives thereof specific for the platelet-derived growth factor receptor .beta.. Methods of use of the antibody, particularly in ameliorating restenosis, are also provided.

Monoclonal antibodies specific for the platelet derived growth factor

Growing community of inventors

Foster City, CA, United States of America

Chung Nan Chang