Lg Life Sciences, Limited

Chung-Mi Kim

Tae-Saeng Choi

Kee-Yoon Roh

Dong-Gyu Cho

Chang-Ho Lee

Jae-Hong Lim

Yong-Zu Kim

Jeong-Min Kim

Hyun-Sook Jang

Tae-Kyun Kim

Jae-Taeg Hwang

Seung-Joo Cho

Gyoung-Won Kim

Woo-Young Cho

Jong-Ryoo Choi

Jin-Ho Lee

Sang-Kyun Lee

Jong-Hyun Kim

Sun-Hwa Lee

Hyun-Ho Chung

Shin-Wu Jeong

Hak-Joong Kim

Hyun-Il Lee

Jong-Sung Koh

Jung-Kwon Yoo

You-Seung Shin

Kwi-Hwa Kim

The present invention relates to an acyclic nucleoside phosphonate derivative which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts, stereoisomers, and a process for the preparation thereof.

Acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same

The present invention relates to an acyclic nucleoside phosphonate derivative represented by the following formula (1): in whichrepresents single bond or double bond, R, R, R, Rand Rare defined herein, Y represents &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;CH(Z)-, &#x2550;C(Z)-, &#x2014;N(Z)-, &#x2550;N&#x2014;, or &#x2014;SiH(Z)-, wherein Z represents hydrogen, hydroxy or halogen, or represents C-C-alkyl, C-C-alkoxy, allyl, hydroxy-C-C-alkyl, C-C-aminoalkyl or phenyl, Q represents a group having the following formula: wherein X, and Xindependently of one another represent hydrogen, amino, hydroxy or halogen, or represent C-C-alkyl, C-C-alkoxy, allyl, hydroxy-C-C-alkyl, phenyl or phenoxy each of which is optionally substituted by nitro or C-C-alkoxy, or represent C-C-arylthio which is optionally substituted by nitro, amino, C-C-alkyl or C-C-alkoxy, or represent C-C-arylamino, C-C-alkylamino, di(C-C-alkyl)amino, C-C-cycloalkylamino or a structure of wherein n denotes an integer of 1 or 2 and Yrepresents O, CHor N&#x2014;R (R represents C-C-alkyl or C-C-aryl), which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts, stereoisomers, and a process for the preparation thereof.

The present invention relates to a nucleoside phosphonate derivative represented by formula (1): pharmaceutically acceptable salts, and stereoisomers. This nucleoside phosphonate derivative is useful as an antiviral agent, particularly, against hepatitis B virus. Also disclosed are processes for the preparation of the nucleoside phosphonate derivative. Also disclosed are methods treating hepatitis B by administering a nucleoside phosphonate derivative of formula (1).

The present invention relates to a novel pyrrole derivative which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof; to a process for preparation of said compound; and to a pharmaceutical composition such as anti-cancer composition, etc. comprising said compound as an active ingredient together with pharmaceutically acceptable carrier.

Pyrrole derivatives useful for farnesyl transferase inhibitors and their preparations

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Taejeon, South Korea

Chung-Mi Kim