Cheiljedang Corp.

Yang Ji Chemical Co., Ltd.

Han Wha Pharma Co., Ltd.

Chung Keun Rhee

Kwang Hyuk Lee

Myung Xik Xiang

Young Gi Kim

Youn Ha Lee

Byoung Chool Suh

Jong Hoon Kim

Jong-Hoon Kim

Yong Sik Youn

Jee Woong Lim

Min-Ho Oak

Jung-Ok Lee

Jung-Duk Sohn

Woon-Sun Choi

Jae Kyu Shin

Byoung Chol Suh

Eui Kyung Kim

The present invention relates to a composition for treatment and prevention of cardiovascular diseases, containing an extract of. More particularly, the extract ofstrongly inhibits NAD(P)H oxidases, which are the main cause of vascular diseases, and at the same time, regulates contraction and relaxation of vascular smooth muscles to manifest a potent vasorelaxant effect, thereby improving the blood pressure regulation and vascular endothelial dysfunction. Therefore, a composition containing this as an active ingredient can be usefully utilized as a pharmaceutical product or health functional food product for the prevention and treatment of cardiovascular diseases.

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The present invention provides novel cathecol hydrazone derivatives of formula (I) or pharmaceutically acceptable salts thereof, wherein R is C alkyl or C cycloalkyl; R is hydrogen, hydroxy, C alkyl or &mdash;CH CH C(&boxH;O)NH ; R and R are independently hydrogen, C alkyl, &mdash;C(&boxH;X)&mdash;R , or 2-, 3- or 4-pyridyl, prymidyl or phenyl substituted with one or two selected from a group consisting of halogen, C alkoxy, nitro, trifluoromethyl, C alkyl and carboxyl, or R and R are directly bonded by C containing oxygen, sulfur or nitrogen to form a heterocyclic ring, X is oxygen, sulfur or NH and R is C alkyl, &mdash;NHR , CONH or 2-, 3- or 4-pyridyl, prymidyl or phenyl substituted with one selected from a group consisting of halogen, C alkoxy, nitrile, trifluoromethyl, C alkyl and carboxyl, and R is hydrogen, hydroxy, NH , C alkoxy, C alkyl, pyridyl or phenyl.

Cathecol hydrazone derivatives, process for preparing the same and pharmaceutical composition containing the same

Novel 4,5-diamino pyrimidine derivatives are described by the following general formula I:

4,5-diaminopyrimidine derivatives and a method for the preparation thereof

A phosphodiesterase IV inhibiting cathecol derivatives of the general formula I: ##STR1## or a pharmaceutically acceptable salt thereof in which R1 is C.sub.1-7 alkyl; C.sub.3-7 cycloalkane; phenyl optionally substituted with lower alkyl lower alkoxy, nitro or halogen; pyrimidine optionally substituted with lower alkyl, lower alkoxy, nitro or halogen; or pyridine optionally substituted with lower alkyl, lower alkoxy, nitro or halogen; X, Y and Z are each independently oxygen, nitrogen or sulfur optionally substituted with C.sub.1-7 alkyl, C.sub.3-7 cycloalkane or phenyl; W is oxygen or sulfur is disclosed. In addition, a process for producing the compound of the general formula I and a pharmaceutical composition containing pharmaceutically effective amount of the compound of the general formula I are disclosed.

Cathecol derivatives and a method for the preparation thereof and a

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Seoul, South Korea

Chung Keun Rhee