Pall Corporation

Gelman Sciences, Inc.

Trillion Science, Inc.

Applied Biocode Inc.

Chung-Jen Hou

Peter Konstantin

Yujing Yang

Xiaosong Wu

Jayesh Dharia

Rong-Chang Liang

Hopin Hu

Winston Z Ho

John J McNamara

Yurong Ying

Qianfei Xu

Charles Gelman

Wilfrid Klaus Wixwat

The present invention relates to substrates for biological testing produced from photo-curable epoxy compositions which further include carboxyl-containing monomers such as acrylic acid, 2-carboxyethyl acrylic acid, 4-vinylbenzoic acid, or 3-Acrylamido-3-methyl-1-butanoic acid, or glycidyl methacrylate, etc. The photo-curable compositions may be used to cast films or fabricate beads, magnetic beads, or magnetic beads containing nickel barcodes. The resulting various kinds of films, beads, magnetic beads, or magnetic beads containing nickel barcodes may find use in clinical or biological applications.

Biocompatible and photocurable polymers

The invention provides an improvement to the useable lifetimes of phenolic-epoxy, phenolic-benzoxazine, phenolic-epoxy-benzoxazine mixtures and other phenolic mixtures through the use of protected phenolics, where a phenolic compound, polymer, or resin is released on demand by the addition of a deblocking agent.

Curable adhesive compositions, process, and applications

An epoxy composition for applications such as one-part adhesives, coatings, prepreg and molding compounds that includes leuco dyes, particularly those comprising a N,N-dialkylamino-, N,N-diarylamino-, N-alkyl-N-arylamino-, N-alkylamino- or N-arylamino- functional group on one of the aromatic rings, as a co- catalyst or co-curing agent. The use of the leuco dye co-catalyst provides improved curing speed of the epoxy composition comprising a latent curing agent/catalyst such as imidazole microcapsules while maintaining the shelf-life stability. The epoxy may also include a secondary co-catalyst that includes a urea, particularly those comprising a N,N-dialkylamino-, N,N-diarylamino-, N-alkyl-N-arylamino- or dicycloalkylamino- functional group. Secondary cocatalysts of low mobility at the storage conditions are particularly preferred. The improved epoxy composition is implemented as adhesives for manufacturing an anisotropic conductive film (ACF) and also for connecting, encapsulating, or packaging of electronic devices.

Epoxy compositions

The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.

Positively charged membrane

The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e.g., from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.

Negatively charged membrane

Filter device and filter element comprising at least one negatively charged membrane

The present invention provides a positively charged microporous membrane having a protein binding capacity about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.

The present invention provides a membrane comprising (a) polymer solids comprising 60 wt. % or more of a fully synthetic organic polymer and optionally about 40 wt. % or less of a polymer of natural origin and (b) a cellulose compound which allows for the detection of a biological molecule of interest, wherein the cellulose compound is uniformly distributed throughout the surface of the membrane. The present invention also provides methods of preparing and using such membranes.

Membrane and methods of preparing and using same

Hydrophilic inter-penetrating network charge modified microporous membranes are provided as well as a method of preparing the membranes by casting a membrane matrix blend containing matrix polymer, a solvent system, a wetting polymer compatible with the matrix polymer, and a charge modified system which forms a cross-linked interpenetrating network structure within the microporous membrane substrate during the membrane fabrication process which network structure optionally can be locked in by heat curing. The membranes are useful for filtering ultrapure water with 18 megaohm-cm resistivity for the electronic industry, and they can also be used for the removal of a variety of contaminants from fluid media, such as very fine negatively charged particles, bacteria and endotoxins, with greatly enhanced filtration efficiency.

Inter-penetrating network charge modified microporous membrane

Hydrophilic inter-penetrating network charge modified microporous membranes are provided as well as a method of preparing the membranes by casting a membrane matrix blend containing matrix polymer, a solvent system, a wetting polymer compatible with the matrix polymer, and a charge modified system which forms a cross-linked inter-penetrating network structure within the microporous membrane substrate during the membrane fabrication process which network structure optionally can be locked in by heat curing. The membranes are useful for filtering ultra pure water with 18 megaohm-cm resistivity for the electronic industry, and they can also be used for the removal of a variety of contaminants from fluid media, such as very fine negatively charged particles, bacteria and endotoxins, with greatly enhanced filtration efficiency.

Growing community of inventors

Pensacola, FL, United States of America

Chung-Jen Hou