Abgenomics Cooperatief U.a.

Yung Shin Pharmaceutical Ind. Co., Ltd.

Abgenomics Corporation

Chung-Hsiun Wu

Rong-Hwa Lin

Pei-Ling Hsu

Fang-Jen Lee

Compounds that bind to P-Selectin Glycoprotein 1 (PSGL-1) on the surface of T cells or natural killer (NK) cells can be used to induce T cell or NK cell depletion and/or to induce T cell or NK cell apoptosis. The compounds and methods of the invention can be used to control unwanted T cell- or NK cell-mediated immune responses in conditions such as autoimmune diseases, transplant rejection, and allergic diseases.

Screening for modulators of PSGL-1 with respect to T cell or NK cell death

Methods of modulating T cell-mediated immune responses with anti-P-selectin glycoprotein ligand 1 antibodies

Methods of modulating T cell or natural killer cell activity with anti-P-selectin glycoprotein ligand 1 antibodies

The invention relates tosuperoxide dismutase antibodies, methods of using them for detection of, methods of testing for an inhibitor of ansuperoxide dismutase, and methods of detecting tuberculosis infection.

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The invention is directed to methods of producing a protein by administering a nucleic acid encoding the protein to an animal. Following the administration of the nucleic acid to the animal, the protein is produced in vivo and is isolated by removing a biological sample from the animal. These methods allow for the rapid and efficient production and isolation of a protein encoded by any nucleic acid sequence of interest and can be used to generate antibodies that bind to the protein sequence.

Production of recombinant proteins in vivo and use for generating antibodies

The invention relates to superoxide dismutase antibodies, methods of using them for detection of , methods of testing for an inhibitor of an superoxide dismutase, and methods of detecting tuberculosis infection.

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Taipei, Taiwan

Chung-Hsiun Wu