Jiangsu Hengrui Medicine Company Ltd.

Shanghai Hengrui Pharmaceutical Co., Ltd.

Chunfei Wang

Ling L Zhang

Fanglong Yang

Feng He

Qing Dong

Weikang Tao

Piaoyang Sun

Yang Wayne Wang

Qiyue Hu

Yang Wang

Mingxun He

Ling Zhang

Jihui Han

The present invention relates to a benzopiperidine derivative, a preparation method thereof and a medical use thereof. In particular, the present invention relates to a benzopiperidine derivative as shown by general formula (I), a preparation method thereof and a pharmaceutical composition containing the derivative, as well as a use thereof as an estrogen receptor modulator in the prevention and/or treatment of estrogen receptor-mediated or dependent diseases or conditions. Preferably, the disease is breast cancer. The substituents in the general formula (I) are the same as those defined in the description. 

Benzopiperidine derivative, preparation method thereof and medical use thereof

Disclosed in the present invention are polycyclic derivatives as represented by general formula (I), the preparation method thereof, pharmaceutical compositions containing the derivatives and uses thereof as therapeutic agents, especially the GPR40 agonist and in preparation of drugs for treating diseases such as diabetes and metabolic disorders, etc., wherein each substituent in the general formula (I) has the same definition as in the description. 

Polycyclic derivatives, preparation process and pharmaceutical use thereof

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Shanghai, China

Chunfei Wang