Merck Frosst Canada, Inc.

Merck Frosst Canada & Co.

Chun-Sing Li

Michel Therien

Jacques Yves Gauthier

Patrick Roy

Yves Leblanc

Cameron Black

Petpiboon Prasit

Cheuk K Lau

Daniel Guay

Michel L Belley

Erich L Grimm

Cheuk-Kun Lau

Zhaoyin Wang

Petpiboon Peppi Prasit

Nathalie Ouimet

W Cameron Black

Pyrones as inhibitors of cyclooxygenase-2

The invention encompasses compounds of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I.

Diphenyl-1,2,3-thiadiazol-3-oxides, compositions and methods of use

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.

(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

The invention encompasses the novel compound of Formula A that is useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula A.

5-Methanesulfonamido-3H-isobenzofuran-1-ones as inhibitors of

The Compound of Formula I and pharmaceutically acceptable salts thereof in the treatment of cyclooxygenase-2 mediated diseases are disclosed.

5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2

The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

Aryl substituted 5,5 fused aromatic nitrogen compounds as

Disclosed are compounds of Formula I useful in the treatment of cyclooxygenase mediated diseases such as pain, fever and inflammation of a variety of conditions including rheumatic fever, symptoms associated with influenza or other viral infections, common cold, low back and neck pain, dysmenorrhea, headache, toothache, sprains and strains, myositis, neuralgia, synovitis, arthritis, including rheumatoid arthritis degenerative joint diseases (osteoarthritis), gout and ankylosing spondylitis, bursitis, burns, injuries. ##STR1##

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Dollard des Ormeaux, Canada

Chun-Sing Li