Korea Research Institute of Chemical Technology

Samyang Corporation

Dongwoo Syntech Co., Ltd

Chun-Rim Oh

Min-sun Lee

Kun Jun

Su-Jin Park

Young-Deuck Kim

Won-Jung Lee

Yong-Il Cho

Seung-Rim Shin

Jong-Il Shin

Sang-Oh Lee

The present invention relates to a novel &#x3b2;-oximester fluorene derivative compound, a photopolymerization initiator comprising the same, and a photoresist composition.

Fluorenyl &#x3b2;-oxime ester compounds, photopolymerization initiator and photoresist composition containing the same

Disclosed is a method for preparing 2'-deoxy-2&#x2032;,2&#x2032;-difluorocytidine of Formula I comprising, preparing an optically pure 3R-hydroxypropane amide compound of Formula VIII from an optical ester compound of Formula IX using an optically active chiral amine, preparing an optically pure D-erythro-2,2-difluoro-2-deoxy-1-oxoribose compound of Formula V from the compound of Formula VIII, glycosylating the compound of Formula V with a nucleobase to prepare the 2&#x2032;-deoxy-2&#x2032;,2&#x2032;-difluorocytidine of Formula I as a &#x3b2;-nucleoside. With the present invention, it is possible to prepare an optically pure compound of Formula I in a high purity and a high yield. In the Formulae, Rand Rare protecting groups and are each independently benzoyl, 4-methylbenzoyl, 3-methylbenzoyl, 4-cyanobenzoyl, 3-cyanobenzoyl, 4-propylbenzoyl, 2-ethoxybenzoyl, 4-t-butylbenzoyl, 1-naphthoyl or 2-naphthoyl, R, Rand Rare each independently C-Calkyl, Ris methyl or ethyl, Ris hydrogen, methyl or methoxy.

Process for preparing 2'-deoxy-2&#x2032;, 2&#x2032;-difluorocytidine

Growing community of inventors

Seoul, South Korea

Chun-Rim Oh