The Hong Kong University of Science and Technology

Hong Kong Baptist University

Macau University of Science and Technology

Chun Liang

Jingrong Wang

Zhihong Jiang

Liping Bai

Zhiling Yu

Dao-rong Feng

Zhi-ling Yu

Ziyi Wang

A method for treating cancer by using an agent which is capable of inhibiting the functionality of the MCM complex, a heterohexameric ring formed from six subunits, in the process of DNA replication and a method of screening for such agents by detecting the locations and functions of the MCM subunits, such as hMcm2 and hMcm6, in cells treated with candidate compounds.

Method and compounds for inhibiting the MCM complex and their application in cancer treatment

Antisense oligonucleotides that inhibit expression of human replication-initiation protein as well as methods of preventing or treating hyperproliferative conditions using said oligonucleotides are disclosed. One aspect provides an antisense oligonucleotides that inhibits the expression of human replication-initiation protein and has a sequence complementary to at least a portion of a target sequence encoding a human replication-initiation gene. By administering a therapeutically effective amount of antisense oligonucleotides or by contacting the hyperproliferating cells with an effective amount of antisense oligonucleotides, expression of replication-initiation protein is inhibited. Methods of screening and testing active antisense oligonucleotides for their ability to inhibit gene expression are also disclosed.

Antisense oligonucleotides targeted to human CDC45

Growing community of inventors

Hong Kong, China

Chun Liang