Korea Research Institute of Bioscience and Biotechnology

The Mclean Hospital Corporation

Chun Hyung Kim

Kwang Soo Kim

Won Gon Kim

Baek Soo Han

Mi Jin Sohn

Kyoung Shim Kim

Young Mi Kang

Hoe Yune Jung

Yu Jin Kim

Deog Joong Kim

The present invention relates to a pharmaceutical composition for preventing or treating Parkinson's disease, which comprises, as an active ingredient, aextract obtained by extracting the stem ofwith an organic solvent, and a food additive showing the effect of preventing or treating Parkinson's disease, the food additive comprisingextract as an active ingredient. Theextracts of the present invention may prevent or treat Parkinson's disease without producing any particular side effects, and therefore can be widely used for more safely treating Parkinson's disease.

Composition containing jetbead extracts

The present invention relates to: a pharmaceutical composition or a Nurr1 activating composition for the prevention or treatment of a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the composition comprises an active ingredient in the form of genkwanin N or yuanhuacine, aextract comprising one or more of the above compounds, or a fraction thereof; or a functional food additive for preventing or alleviating a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the additive comprises genkwanin N or yuanhuacine, aextract comprising one or more of the above compounds, or a fraction thereof; and a method for the prevention or treatment of a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the method comprises the step of administering the pharmaceutical composition.

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The invention features methods and kits for treating or inhibiting the development of Parkinson's Disease by administering 7-chloro-4-aminoquinoline compounds, e.g., amodiaquine or glafenine. Stem cells are also useful in the methods of the invention and may be administered separately from or together with 7-chloro-4-aminoquinoline compounds. The invention further features methods of identifying additional chemical compounds that are useful in the treatment or inhibition of the development of Parkinson's Disease.

Methods and compositions for the treatment of Parkinson's Disease

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Lexington, MA, United States of America

Chun Hyung Kim