Sk Biopharmaceuticals Co., Ltd.

Sk Corporation

Sk Holdings Co., Ltd.

Chun-Eung Park

Won Hee Kim

Yu-Jin Shin

Eun-Ju Ryu

Hae-Jeong Yoon

Yong-Je Shin

Coo-Min Chung

Kyung-Hyun Min

Ki-Ho Lee

Hui-Ho Kim

Yong-Moon Choi

Yong-Kil Kim

Won Sik Kim

Joon Heo

Kyung-Hyan Min

Eun-Ho Lee

Sung-Yong Seo

Jin-Uk Yoo

Eun-Ah Paek

There are disclosed racemic or enantiomerically enriched 3- or 4-substituted piperidine compounds represented by the following structural formula (I): or any of their isomers, or pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions containing the subject compounds. The subject compounds are useful for the treatment of diseases of the central nervous system, particularly depression, anxiety and pain disorder.

3 or 4-substituted piperidine compounds

Racemic or enantiomerically enriched 3-substituted propanamine compounds represented by the following structural formula (I): or a pharmaceutically acceptable salt thereof are disclosed. Pharmaceutical compositions containing the subject compounds are also disclosed. The subject compounds are useful for the treatment of diseases of the central nervous system, such as depression, anxiety and pain disorders.

3-substituted propanamine compounds

The present invention relates to novel 1,2- or 1,3-diamine and amide compounds and pharmaceutically useful salts thereof and methods for treating central nervous system diseases. The present 1,2- or 1,3-diamine and amide compounds have high binding affinity to the sigma receptor.

Phenylalkyl diamine and amide analogs

Provided herein are racemic or enantiomerically enriched benzoyl piperidine compounds and pharmaceutically useful salts thereof, pharmaceutical compositions comprising an effective amount of racemic or enantiomerically enriched benzoyl piperidine compounds to treat central nervous system diseases and methods of treating central nervous system diseases in a mammal, in particular psychoses and cognition disorders.

Benzoyl piperidine compounds

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Seoul, South Korea

Chun-Eung Park