Atomic Energy Council-institute of Nuclear Energy Research

Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.o.c

Institute of Nuclear Energy Research, Atomic Energy Council

Chun-Chia Cheng

Shui-Cheng Lee

Shiau-Shiun Guan

Siao-Syun Guan

Hsien-Ming Wu

A bonding method is provided for gold nanoparticles (GNPs). GNPs are bonded with diethylenetriamine pentaacetic acid (DTPA). GNPs have high bio-compatibility and high surface area. Hence, the present invention uses GNPs as carriers for diagnosing and treating cancer.

Method of bonding gold nanoparticles with diethylenetriamine pentaacetic acid

The present disclosure describes techniques used for colorectal cancer detection. Position and distribution of colorectal cancer tumor are detected through nuclear imaging. Alternatively, stage of colorectal cancer is identified by shading value in tumor. Thus, the present disclosure provides a safe and noninvasive clinical method for diagnosing and tracing level and distribution of colorectal cancer before and after treatment.

Method of colorectal cancer detection by using radiolabeled anti-GRP78 peptide

Human neutrophil peptide (HNP) 1-3, used as diagnostic and therapeutic molecular probes, are found in clinical tissues of gastric cancer patients. In the analytical process according to the present disclosure, pairs of gastric cancer tissues are used to seek the putative biomarkers by proteomic strategy based on matrix assisted laser desorption ionization-imaging mass spectrometry (MALDI-IMS). Then, three differential biomarkers, including HNP-1, -2 and -3, are identified (P&#x3c;0.001) and overexpressed in gastric cancer. At last, western blotting and immunohistochemistry are used to validate the protein expression in gastric cancer tissues. In conclusion, the use of the up-regulated proteins, HNP1-3, helps diagnosis and therapy in clinical for gastric cancer after validating the sensitivity and specificity.

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Taoyuan County, Taiwan

Chun-Chia Cheng