Biomendics, LLC

Kent State University

Other

Northeastern Ohio University

Summa Health System

Chun-che Tsai

James M Jamison

Karen M McGuire

Jack L Summers

John J Docherty

Aleesha M McCormick

Emily L Plocinik

Jackie L Summers

Methods and compounds are disclosed for wound healing by modulating autophagy. A formulation for modulating autophagy comprises a first modulating compound (FAM) selected from compounds having the general structure (I):

Formulation and process for modulating wound healing

Described are methods for disinfecting a physical or biological surface by contact with an antimicrobial formulation comprising a substituted tolan compound, the substitutions being, for example, one or more alkoxy, (e.g., methoxy) and hydroxy substituents at one or both phenyl rings of the tolan. The compounds and methods are -static and/or -cidal, depending on dose and suspected microbe. Suspected pathogenic microbes include Gram negative bacteria, such asand, Gram positive bacteria, such as, including MRSA, and fungal pathogens, such as Candida genus and. Also described are methods for inhibiting or disrupting biofilm formation of a microbe or microbes.

Substituted tolans for the modulation of microbial colonization

Methods and compounds are disclosed for wound healing by modulating autophagy. A formulation for modulating autophagy comprises a first modulating compound (FAM) selected from compounds having the general structure (I):  Rto Rare independent substituents at any available position of the phenyl rings, preferably at 3, 3', 4, 4&#x2032;, and/or 5, 5&#x2032;; and m, n, p, and q are independently 0, 1, 2, or 3 representing the number of substituents of the rings, respectively, but at least one of m or n must be &#x2265;1. Each Rto Ris independently selected from substituents described herein, including but not limited to hydroxyl, alkoxy, halo, halomethyl and glycosides. The formulation may also include an auxiliary autophagy modulating compound (AAM) as described herein. The formulation may include a hydrogel formed by the compounds themselves or otherwise and may include salts and/or complexes.

Methods and compounds are disclosed for wound healing by modulating autophagy. A formulation for modulating autophagy comprises a first modulating compound (FAM) selected from compounds having the general structure (I): 

Compounds of the hydroxytolan family kill tumor cells, inhibit tumor growth and development, and are thus useful in method for treating a tumor or cancer in subjects in need thereof. These compounds are also active in preventing or treating a variety of skin diseases and conditions. The most preferred hydroxytolan compounds are 4,4'-dihydroxytolan. (KST-201), 4 hydroxy 4&#x2032; trifluoromethyltolan or 4&#x2032; hydroxy 4 trifluoromethyltolan (KST-213), 3,4&#x2032;,5-trihydroxytolan or 3&#x2032;,4,5&#x2032;-trihydroxytolan (KST-301) and 3,3&#x2032;,5,5&#x2032;-tetrahydroxytolan (KST-401). The compounds and methods of using them alone and in combination with ascorbate and certain cyclic compounds to inhibit the development, growth or metastasis of tumor/cancer or preneoplastic cells, or to prevent or treat skin disorders in a subject are disclosed.

Hydroxylated tolans and related compounds in the treatment of a cancer

The combination of compounds of the hydroxytolan family with ascorbate plus naphthoquinone (Vitamin K3; VK3), or a quinone or semiquinone analogue of VK3, kill tumor cells, inhibit tumor growth and development, and treat cancer in subjects in need thereof.

Ascorbate, vitamin K3 and hydroxytolans in the treatment of cancer

The present invention provides a method of inhibiting the formation of infectious herpes virus particles, particularly infectious herpes simplex virus (HSV) particles, in a host cell. The method involves administering an effective amount of a hydroxylated tolan, particularly a polyhydroxylated tolan, to a herpes virus infected host cell. The present invention also provides a method of treating a herpes virus infection, particularly an HSV infection. The method comprises administering a topical composition comprising a therapeutically effective amount of a hydroxylated tolan to a herpes virus-infected site. The present invention also relates to a topical composition for treating a herpes virus infection selected from the group consisting of an HSV infection, a cytomegalovirus infection, and a varicella zoster virus infection. The present invention also provides a method of treating a subject infected with

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Kent, OH, United States of America

Chun-che Tsai