General Electric Company

Chulmin Joo

Siavash Yazdanfar

Evgenia Mikhailovna Kim

Sora Kim

Robert John Filkins

Vasile Bogdan Neculaes

Adrian Ivan

Brian Michael Davis

Allen Lawrence Garner

Brent Allen Clothier

Kenneth Roger Conway

Dmitry Vladimirovich Dylov

Evelina Roxana Loghin

Daniel Bruno McDevitt

Robert John Fikins

A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal. Further, the OCT imaging system includes a controller having logic configured to perform an auto-ranging process to match the reference arm with the sample arm.

System and method for auto-ranging in optical coherence tomography

Some systems described herein include a frequency dependent phase plate for generating multiple phase-contrast images of a sample, each from a different frequency range of light, each phase-contrast image for frequency range of light formed from light diffracted by the sample interfered with undiffracted light that has a frequency-dependent baseline relative phase shift from the phase plate. In some embodiments, the multiple phase-contrast images may be used to generate a quantitative phase image of a sample. The phase-contrast images or the produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.

Quantitative phase microscopy for high-contrast cell imaging using frequency domain phase shift

A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal at a detector. Further, the OCT imaging system includes a controller having logic configured to perform an auto-focusing process to determine the optimal position for a lens in the sample arm in order to bring the sample into focus.

System and method for auto-focusing in optical coherence tomography

A method of delivering exogenous molecules, comprising: providing a plurality of cells having a cell membrane; adding a plurality of exogenous molecules to the cells; exposing the cells to a defocused infrared (IR) light to permeabilize the cell membrane of the cells; and delivering the exogenous molecules to the cells through the permeablized cell membrane, wherein an intensity of the IR light at the optical focus is at least greater than or equal to an order of 10W/cm.

Optical based delivery of exogenous molecules to cells

Systems and methods described herein employ multiple phase-contrast images with various relative phase shifts between light diffracted by a sample and light not diffracted by the sample to produce a quantitative phase image. The produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.

Quantitative phase microscopy for label-free high-contrast cell imaging

A radiation detector includes a neutron sensing element comprising a neutron scintillating composite material that emits a first photon having a first wavelength and an optical waveguide material having a wavelength-shifting dopant dispersed therein that absorbs the first photon emitted by the neutron scintillating composite material and emits a second photon having a second, different wavelength, and a functionalized reflective layer at an interface between the neutron scintillating composite material and the optical waveguide material. The functionalized reflective layer allows the first photon emitted by the neutron scintillating composite material to pass through and into the optical waveguide material, but prevents the second photon emitted by the optical waveguide material from passing through and into the neutron scintillating composite material. The photons emitted from the neutron sensing element are collected and channeled through the optical waveguide material and into a photosensing element optically coupled to the neutron sensing element.

Growing community of inventors

Kyunggi-do, South Korea

Chulmin Joo