Global Blood Therapeutics, Inc.

Chul Yu

Zhe Li

Hing L Sham

Qing Xu

Ming Yu

Calvin Wesley Yee

Lina Quattrocchio Setti

Manuel Zancanella

Brian Walter Metcalf

Stephen L Gwaltney, Ii

Matthew A Lardy

Steven Richards

The present disclosure provides certain angular tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Azaindole compounds as histone methyltransferase inhibitors

Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.

Bridged bicyclic kallikrein inhibitors

In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X, L, L, and Rare described herein.

Pyrazolopyridine pyrazolopyrimidine and related compounds

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San Ramon, CA, United States of America

Chul Yu