Korea Institute of Science and Technology

Korea Institute of Ocean Science & Technology

Chul Soo Shin

Ae Nim Pae

Yong Seo Cho

Joung Han Yim

Se Jong Han

Hun Yeong Koh

Ha Ju Park

Joo Hwan Cha

Il-Chan Kim

Jun Hyuck Lee

Dockyu Kim

Bon-Hun Koo

A cold-adapted protease derived fromPAMC 21717 or a recombinant cold-adapted protease obtained by expressing a gene encoding the cold-adapted protease inis described, and more particularly, a crystal of a protease exhibiting activity at low temperatures, a method for crystallizing the protease, a method for preparing the protease, a recombinant microorganism that expresses the protease, a method for preparing the recombinant microorganism, a method for preparing the recombinant protease and the use of the cold-adapted protease. The cold-adapted protease exhibits high activity at low temperatures, and securely maintains its enzymatic activity even in the presence of high pH, various metal ions and surfactants. Thus, it is useful in various industrial applications.

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The present invention relates to bicyclic tetrahydrofuran derivatives of Formula (1) and a preparation method thereof, and particularly it relates to a process of preparing compounds of Formula (1) by performing an intramolecular cyclization of tetrahydrofuran-allenol derivatives in the presence of alcohol compound, transitional metal catalyst and carbon monoxide: wherein n is 1 or 2; R is phenyl optionally substituted with C-Calkyl, C-Calkoxy, hydroxyl or C-Chydroxyalkyl group; and Ris C-Calkyl group.

Bycyclic tetrahydrofuran derivatives and process for the preparation thereof

The present invention relates to bicyclic tetrahydrofuran lactone derivatives of Formula (1) and a preparation method thereof, and particularly it relates to a process of preparing compounds of Formula (1) by performing an intramolecular cyclization of tetrahydrofuran-allenic acid derivatives in the presence of a phenyl halide, a palladium catalyst and a base: wherein n is 1 or 2, and R is phenyl optionally substituted with C&#x2013;Calkyl, C&#x2013;Calkoxy, hydroxyl or C&#x2013;Chydroxyalkyl group.

Bicyclic tetrahydrofuran lactone derivatives and process for the preparation thereof

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Gyeonggi-do, South Korea

Chul Soo Shin