Korea Research Institute of Bioscience and Biotechnology

Korea Aerospace Research Institute

Keimyung University Industry Academic Cooperation Foundation

Chul Kang

Tae Kwang Oh

Young Jun Cho

Jung-Hoon Yoon

Sang Burm Ryu

Young Jin Won

Sang Kon Lee

Jeong Hwan Yang

Young Chul Kim

Jong Pyo Kim

Eun Ye Park

Ki Hoon Oh

Mi Hwa Lee

Sang Nam Kim

The present invention relates to an apparatus and method for generating a bidirectional chirp signal by using a phase accumulation polynomial, and the apparatus for generating a bidirectional chirp signal according to an embodiment may include an extraction unit extracting time interval information from the output of a frequency accumulator, a polynomial handling unit applying the phase accumulation polynomial to the extracted time interval information to generate a polynomial output value, and a bidirectional chirp signal output unit outputting a bidirectional chirp signal on the basis of the generated polynomial output value.

Apparatus and method for generating bidirectional chirp signal by using phase accumulation polynomial

The present invention relates to a novel gene derived from a tidal flat metagenome, and a novel protein obtained therefrom showing the coactivity of phospholipase and lipase. Specifically, the novel gene isolated from the metagenome library of tidal flat sediments and the protein having phospholipase and lipase activities encoded from the novel gene: are expressed in a water-soluble form to be mass-producible; enable ultra high-purity protein to be obtained through single step purification using an Ni-NTA column; show good activity in the pH range of 5&#x2dc;10; maintain good low temperature activity and stability up to a temperature of 3&#xb0; C. to 40&#xb0; C.; and have high resistance against various organic solvents. Therefore, the novel gene and the protein can be usefully used for various industrial fields such as the purification and conversion of oil and fat, bio-medicine, and fine chemistry.

Gene from tidal flat metagenome and a novel protein displaying both phospholipase and lipase activities

Disclosed is a composition for treating or preventing vitiligo or canities comprisingextract as an active ingredient. Theextract enhances melanin synthesis by increasing the activity of tyrosinase which is critical in intracellular melanin synthesis and promoting the expression of tyrosinase and TRP-2 mRNA. Furthermore, since theextract is a natural substance with little cytotoxicity, it may be developed into a therapeutic agent for vitiligo and canities caused by depigmentation in skin and hair.

Composition for treating vitiligo or canities comprising extract from sophora japonica as active ingredient

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Daejeon, South Korea

Chul Kang