Korea Research Institute of Bioscience and Biotechnology

Korea Institute of Science and Technology

Healthbiome

Chul-Ho Lee

Yang-Kyu Choi

Tae-Sook Jeong

Myung-Sook Choi

Song-Hae Bok

Surk-Sik Moon

Byung-Hwa Hyun

Yong-Kook Kwon

Yong-Bok Park

Ki-Hwan Bae

Eun-Sook Lee

Sae-Bom Lee

Young-Bae Park

Hyo-Soo Kim

Kyeong Seok Lee

Young Kook Kim

Jung Joon Lee

Mun-Chual Rho

Hyun Sun Lee

Yongseok Choi

Jeong Hyung Lee

Hye-Ran Park

Byung-Tae Ahn

Jung Hwan Hwang

Yong-Hoon Kim

Sang Jun Lee

Kwang-Hee Son

Byoung-Mog Kwon

Sung-Gyu Kim

Young-Kook Kim

Og-Sung Moon

Doo-Sang Park

Sung-Uk Kim

Ingyu Hwang

Doil Choi

Jung-Ah Ahn

Jung-Hyeon Choi

Young Soo Hong

Yun-Jung Seo

In-Bok Lee

Jun Go

Hye-Yeon Park

Young-Kyoung Ryu

Sang-Ku Lee

Jung-Ran Noh

Moon-Soo Rhee

Ju-Ryong Kim

Jun-Sung Lee

Byoung-Chan Kim

Kyoung-Shim Kim

Seong-Choon Choe

Myung-Hee Kim

Dong-Ho Chang

Dong-Hee Choi

Young-Keun Choi

Provided are ansp. strain having prophylactic or therapeutic effects on degenerative brain diseases, and use thereof. Since the intestinal microorganismSR79 strain of the present invention may have effects of inhibiting neuroinflammation and effects of improving movement regulation and cognitive and memory functions in animal models with degenerative brain diseases such as Parkinson's disease and Alzheimer's disease, the strain may be effectively used in foods, medicines, or feeds for preventing or treating brain diseases including Alzheimer's disease, Parkinson's disease, mild cognitive impairment, etc., and therefore, it is very useful in the relevant industries.

sp. strain having prophylactic or therapeutic effects on degenerative brain diseases and use thereof

Disclosed is a composition for the prevention and treatment of metabolic diseases, which comprises a benzazole derivative as an active ingredient. The benzazole derivative has inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, thus, the composition is useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.

Method for the treatment of metabolic disorder containing benzazole derivatives as an active ingredient

Disclosed are indole derivatives, a preparation method thereof, and a composition for the prevention and treatment of metabolic diseases, containing the same as an active ingredient. The indole derivatives have inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, the composition is thus useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.

Indol derivatives, the method for preparing thereof and composition for the prevention and treatment of metabolic disorder containing the same as an active ingredient

0A method for treating or preventing an elevated blood lipid level-related disease in a mammal, which comprises administering thereto an effective amount of rutin, quercetin or a mixture thereof.

Method for preventing or treating elevated blood lipid level-related diseases by administering rutin and quercetin

A method for treating or preventing an elevated blood lipid level-related disease in a mammal, which comprises administering thereto an effective amount of rutin, quercetin or a mixture thereof.

The present invention relates to a spice composition comprising 1 to 30 % by weight of garlic, 10 to 50% by weight of onion, 0.2 to 10% by weight of ginger, 5 to 40% by weight of jujube, and 10 to 50% by weight of citrus peel or an extract thereof or 1 to 20% by weight of naringin or hesperidin.

Health-improving spice composition

Flavanone derivatives and composition for preventing or treating blood lipid level-related diseases comprising same

A method for treating or preventing an elevated blood lipid level-related disease such as hyperlipidemia, arteriosclerosis, angina pectoris, stroke and hepatic diseases in a mammal, which comprises administering thereto an effective amount of a cinnamic acid derivative of formula Ia or Ib, or a pharmaceutically acceptable salt thereof:

Method for preventing or treating elevated blood lipid level-related diseases by administering cinnamic acid derivatives

Methods for inhibiting the activity of acyl CoA-cholesterol-o-acyltransferase, inhibiting the accumulation of macrophage-lipid complex on the arterial endothelium, and preventing or treating hepatic diseases in a mammal comprise administering naringin or naringenin thereto.

Naringin and naringenin as inhibitors of acyl

A method for increasing the plasma high density lipoprotein(HDL) level in a mammal comprises administering a bioflavonoid of formula(I) or plant extract containing same thereto: ##STR1## wherein, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5.sub.7 R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are each independently hydrogen; a hydroxy group; a C.sub.1-9 alkoxy group optionally substituted with one or more substituents selected from the group consisting of a hydroxy, C.sub.1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.5-9 cycloalkyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.5-9 cycloalkylcarbonyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.2-10 or C.sub.16-18 acyloxy group optionally substituted with one or more substituents selected from the group consisting of a hydroxy, C.sub.1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen and nitro group; a rutinosyl group; or a rhaminosyl group; and

Bioflavonoids as plasma high density lipoprotein level increasing agent

A method for treating or preventing an elevated blood lipid level-related diseases such as hyperlipidemia, arteriosclerosis, angina pectoris, stroke and hepatic diseases in a mammal, which comprises administering thereto an effective amount of tannin, gallic acid or ellagic acid.

Method for preventing or treating elevated blood lipid level-related

A method for lowering the blood glucose level in a mammal comprises administering an effective amount of a hesperetin or naringenin bioflavonoid.

Method for lowering blood glucose level by the administration of

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Daejeon, South Korea

Chul-Ho Lee