Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Chuk Chui Man

Hidenori Takahashi

Tina Marie Morwick

Xin Guo

Ming-Hong Hao

Zhidong Chen

Peter Allen Nemoto

Pui Leng Loke

Stephane De Lombaert

Michel Jose Emmanuel

Ho Yin Lo

Asitha Abeywardane

Steven John Taylor

Weimin Liu

Michael Robert Turner

Renee M Zindell

Hossein Razavi

Lifen Wu

Robert Sibley

Roger John Snow

Thomas Martin Kirrane, Jr

Erick Richard Roush Young

Angela Kay Berry

Heather Tye

Ronald John Sorcek

Michael Jason Burke

Yunlong Zhang

Daniel Richard Marshall

Lana Louise Smith Keenan

Anil Kumar Padyana

Brian Nicholas Cook

Qiang Zhang

Steven Richard Brunette

Jin Mi Kim

Kevin Chungeng Qian

Ho-Yin Lo

Tina Morwick

Michael Jason Bruke

The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A, A, Land B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene Ahydrolase (LTAH) and treating LTAH related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

Inhibitors of leukotriene production

Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.

Benzimidazolone chymase inhibitors

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, R, R, R, R, Rand Rare as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Biarylamide inhibitors of leukotriene production

Disclosed are small molecule inhibitors of the formula (I), which are useful in treating various diseases and conditions involving chymase. 

Azaquinazolinediones chymase inhibitors

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salt thereof, wherein R-Rare as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Benzimidazole inhibitors of leukotriene production

Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving Chymase.

Quinazolinedione chymase inhibitors

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Ridgefield, CT, United States of America

Chuk Chui Man