Glaxo Group Limited

Smithkline Beecham Corporation

Chuen Chan

Nigel Stephen Watson

Andrew McMurtrie Mason

Henry Anderson Kelly

Robert John Young

Nigel Paul King

Stefan Senger

Caroline Whitworth

Julie Nicole Hamblin

Vipulkumar Kantibhai Patel

Gita Punjabhai Shah

Helen Elisabeth Weston

Brian Cox

Richard Peter Charles Cousins

Joanna Victoria Geden

Alan D Borthwick

Hazel Joan Dyke

David E Bays

Suzanne Elaine Keeling

Barry C Ross

Stephen Swanson

Alison Judith Redgrave

David George Allen

Frank Ellis

Caroline Mary Cook

Savvas Kleanthous

Heather Hobbs

Matthew Campbell

Shiping Xie

Paul William Smith

Thomas Davis Roper, Iv

Richard Charles Peter Cousins

The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.

Pyrrolidine derivatives as factor Xa inhibitors

The invention relates to compounds of formula (I): wherein substituents are as defined.

1-Phenyl-2-oxo-3-sulfonylamino-pyrrolidine derivatives and related compounds as factor Xa inhibitors for the treatment of acute vascular diseases

Pyrrolidine derivatives as factor XA inhibitors

The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.

Pyrrolidin-2-one derivatives as inhibitors of factor xa

Pyrrolidine derivatives as Factor Xa inhibitors

The invention relates to compounds of formula (I) pharmaceutical compositions containing the same as well as methods of treating patients suffering from a condition susceptible to amelioration by a Factor Xa inhibitor using the same. 

2-(3-sulfonylamino-2-oxopyrrolidin-1-yl)propanamides as factor xa inhibitors

Pyrrolidin-2-one derivatives as inhibitors of factor Xa

There are provided according to the invention, novel compounds of formula (I) wherein R , R and R are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory disease.

2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives

There are disclosed according to the invention, compounds of formula (I) wherein R , R and R are defined in the specification. Additionally, processes of preparing the compounds of formula (I), formulations containing same, and the administration of said compounds or formulations thereof in the treatment of inflammatory diseases are also disclosed.

2-(purin-9-yl)-tetrahydrofuran-3, 4-diol derivatives

A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a receptor are described.

2-(purin-9-yl)-Tetrahydrofuran-3,4-diol derivatives

A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2 receptor are described.

2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives

This invention relates to imidazole derivatives having hypocholesterolemic and hypolipidemic activity, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine, particularly in the treatment and/or prevention of atherosclerosis and coronary heart disease.

Imidazole derivatives

Compounds of formula ##STR1## wherein R.sup.1 or R.sup.2 represents a C.sub.1-6 alkyl group optionally substituted by one to three halogen atoms and the other represents a phenyl or pyridyl ring or N-oxide thereof optionally substituted by one or more substituents selected from halogen atoms and hydroxyl, C.sub.1-3 alkyl, C.sub.1-3 alkoxy and trifluoromethyl groups; wherein R.sup.3 represents a phenyl or pyridyl ring or N-oxide thereof optionally substituted by one or more substituents selected from halogen atoms and hydroxyl, C.sub.1-3 alkyl, C.sub.1-3 alkoxy and trifluoromethyl groups with the proviso that only one of the groups R.sup.1, R.sup.2 or R.sup.3 represents an optionally substituted pyridyl ring; X represents --CH.dbd.CH--; and Z represents ##STR2## wherein R.sup.4 represents a hydrogen atom, a carboxyl protecting group or a cation; and R.sup.5 represents a hydrogen atom or a C.sub.1-3 alkyl group; a solvate thereof, or acid addition salts of compounds wherein R.sup.4 represents a hydrogen atom or a carboxyl protecting group; for use in the treatment and/or prevention of diseases associated with hypercholesteroloma and hyperlipoproteinemia.

Imidazole derivatives and their use as hypercholesterolemia and

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Stevenage, United Kingdom

Chuen Chan