Columbia University

Government of the United States of America, as Represented by the Secretary of Commerce

Chuanjuan Tao

Jingyue Ju

Shiv R Kumar

James J Russo

Minchen Chien

Sergey M Kalachikov

Zengmin Li

Xiaoxu Li

Shundi Shi

Min-Kang Hsieh

Jianyi Ren

Cheng Guo

Xin Chen

Ece Erturk

Jacob Karl Rosenstein

Steffen Jockusch

Ken Shepard

John J Kasianowicz

Joseph W F Robertson

Irina Morozova

Youngjin Cho

Xuanting Wang

John J Kasianovicz

Joseph WF Robertson

Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

Nucleotide derivatives and methods of use thereof

The invention provides various orthogonal nucleotide analogues and methods for using combinations of said various orthogonal nucleotide analogues for sequencing by synthesis.

Nucleotide analogues and use thereof for nucleic acid sequencing and analysis preliminary class

This disclosure is related to a method of sequencing a single-stranded DNA using deoxynucleotide polyphosphate analogues and translocation of tags from incorporated deoxynucleotide polyphosphate analogues through a nanopore.

DNA sequencing by synthesis using modified nucleotides and nanopore detection

Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis

This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.

Method of preparation of nanopore and uses thereof

This invention provides methods for detecting the presence of a plurality of predetermined compounds in a sample using a plurality of tag moieties and at least one nanopore. This invention also provides methods for determining the quantity of each of a plurality of predetermined compounds in a sample using a plurality of tag moieties and at least one nanopore. This invention further provides methods for detecting interaction of at least two predetermined compounds using at least one tag moiety and at least one nanopore.

Method for detecting multiple predetermined compounds in a sample

This invention provides methods of using labeled primers or probes for nucleic acid target detection and to detect the identity or presence of a nucleotide at certain positions in nucleic acid sequences with single molecule sensitivity using nanopore detection, and sets of oligonucleotide primers for use in such methods, as well as methods of quantitative PCR coupled with nanopore detection.

Single molecule electronic multiplex SNP assay and PCR analysis

This invention provides methods of using labeled nucleotide polyphosphate analogues to detect the identity or presence of a nucleotide at certain positions in nucleic acid sequences with single molecule sensitivity using nanopore detection, nucleotides and primer-conjugated nanopore proteins for use in such methods, and processes for producing such nucleotides and primer-conjugated nanopore proteins.

Polymer tagged nucleotides for single molecule electronic SNP assay

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Chuanjuan Tao