Chinese Academy of Sciences

Tianjin Chase Sun Pharmaceutical Co., Ltd

Chongqing University

Chinese Academy of Medical Sciences

Chuan Zhou

Yang Yang

Yi Zheng

Ling Li

Xiaoguang Chen

Ming Ji

Fangfang Lai

Nina Xue

Zhiqiang Feng

Hao Chen

Ke Fei Wang

Bin Wang

Ke Wang

Jianda Shao

Hongji Qi

Duanyang Chen

Lijing Zhang

Hang Liu

Huawei Yin

Mingwei Li

Xiaofeng Jin

A method for growing long-seed DKDP crystal by two-dimensional motion grows the crystal along the cylindrical surface, and there is no cylinder-cone interface with low optical quality, while avoiding three flow regions which are inevitable in the crystal growth process by rotating crystal method, including incident flow, side flow and wake flow, and easily cause inclusion formation. The long seed crystal moves periodically in the fresh solution, four cylindrical surfaces can achieve reversible shear flow in one cycle, and any point on the cylindrical surface experiences the same hydrodynamic conditions in one movement cycle, so that the solute supply is sufficient and uniform, the growth velocity is improved, and the stability of morphology is ensured. The method facilitates rapid growth of high quality DKDP crystals and provides a better solution for the large-size, high-quality DKDP crystal growth required by the ICF laser device.

Method for growing long-seed DKDP crystal by two-dimensional motion

The present invention discloses a nicotinyl alcohol ether derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the invention relates to nicotinyl alcohol ether derivatives represented by formula (I), a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, a preparation method therefor, a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases. 

Nicotinyl alcohol ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof

The present invention discloses a phenylate derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the invention relates to phenylate derivatives represented by formula (I), a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, a preparation method therefor, a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases. 

Phenylate derivative, preparation method therefor, and pharmaceutical composition and uses thereof

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Beijing, China

Chuan Zhou