International Business Machines Corporation

Agency for Science, Technology and Research

National University of Singapore

Coral Bay Ii, Llc.

Agency for Science, Technology

Chuan Yang

Yi Yan Yang

James L Hedrick

Nathaniel H Park

Victoria A Piunova

Pang Kern Jeremy Tan

Mareva B Fevre

Xin Ding

Wei Cheng

Jeannette M Garcia

Fabian F Morgan

Zhe Yan

Danny Y Chen

Sarah White Eagle

Dan Dan Zheng

Cherylette Anne Alexander

Dylan J Boday

Rudy J Wojtecki

Amanda Catherine Engler

Daniel Joseph Coady

James Lupton Hedrick

Gavin O Jones

Mark Kunitomi

Simone Bianco

Zhen Chang Liang

Ashlynn Lingzhi Lee

Jye Yng Teo

Jiayu Leong

YiYan Yang

Ichiyama Koji

Naoki Yamamoto

Pei Yun Teo

Paola Florez De Sessions

Balamurugan Periaswamy

Yiran Zhen

Kam W Leong

Nianjun Zhou

Alshakim Nelson

Dikran S Meliksetian

Yang Sun

Jun Li

Robert J Ono

Ashlynn L Z Lee

Xin Wang

Victor W L Ng

Yi-Yan Yang

Shaoqiong Liu

Nor Lizawati Ibrahim

Suat Hong Goh

Hongzhe Li

Techniques regarding a chemical composition that can be utilized within one or more combination therapies to treat a microbial infection are provided. For example, one or more embodiments described herein can comprise a chemical composition that includes a first triblock polymer comprising a quaternary ammonium functionalized polycarbonate block and exhibiting anticancer activity via a lytic mechanism. The chemical composition can also include a second triblock polymer comprising a guanidinium functionalized polycarbonate block and exhibiting anticancer activity via a translocation mechanism.

Combination therapies that enhance antimicrobial/anticancer activities

Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.

Utilizing polymers and antibiotics to enhance antimicrobial activity and inhibit antibiotic resistance

Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.

Polylysine polymers with antimicrobial and/or anticancer activity

Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.

Polymers with antimicrobial functionalities

A method for formation of a vaccine comprising combining a cationic polymer adjuvant with an antigen to form first immunoparticles through charge interactions and producing a treatment formulation for the vaccine comprising the first immunoparticles.

Biodegradable cationic polycarbonates as adjuvants for vaccines

Techniques regarding killing of a pathogen with one or more ionene compositions having antimicrobial functionality are provided. For example, one or more embodiments can comprise a method, which can comprise contacting amicrobe with a chemical compound. The chemical compound can comprise an ionene unit. Also, the ionene unit can comprise a cation distributed along a molecular backbone. The ionene unit can have antimicrobial functionality. The method can further comprise electrostatically disrupting a membrane of themicrobe in response to the contacting.

Chemical compositions with antimicrobial functionality

The present invention mainly relates to a polymer for delivery of biologically active materials, a complex and a method of synthesis thereof. The polymer comprises a poly(ethylene imine) and at least one monomer, each monomer comprising a modified sugar moiety, preferably galactose, comprising a sulphur atom or a nitrogen atom and a chemical moiety comprising a terminal epoxide for linking the polyethylene imine to the monomer, wherein the sulphur atom or the nitrogen atom links the modified sugar moiety to the chemical moiety. The biologically active material is preferably a gene, siRNA, mRNA or plasmid DNA. Further disclosed is the medical use of said complex in treating a disease caused by a genetic disorder, for example cancer.

Polymer for delivery of biologically active materials

Embodiments of the invention are directed to a macromolecular chemotherapeutic. A non-limiting example of the macromolecular chemotherapeutic includes a block copolymer. The block copolymer can include a water-soluble block, a cationic block, and a linker, wherein the linker is connected to the water-soluble bock and the charged block.

Macromolecular chemotherapeutics

Techniques regarding enhancing antimicrobial activity of antirheumatic agents by combination therapy are provided. For example, one or more embodiments described herein can regard a chemical composition comprising a polycarbonate polymer functionalized with a guanidinium functional group. The chemical composition can also comprise an antirheumatic agent, and the polycarbonate polymer can enhance an antimicrobial activity of the antirheumatic agent.

Combination therapy to achieve enhanced antimicrobial activity

Compositions and methods regarding guanidinium functionalized polycarbonates that provide potent antimicrobial activity against multidrug resistant (MDR) bacteria, including() are provided. According to an embodiment, an antimicrobial guanidinium-functionalized polymer is provided that comprises a hydrophobic molecular backbone with cationic guanidinium moieties respectively bound to the hydrophobic molecular backbone via butyl spacer groups. The antimicrobial guanidinium-functionalized polymer self-assembles into a micelle structure with hydrophobic residuals of the antimicrobial guanidinium-functionalized polymer buried inside the micelle structure and the cationic guanidinium moieties exposed on an external surface of the micelle structure to target pathogens.

Antimicrobial polycarbonates for multidrug resistant bacteria

The disclosure describes methods and therapeutic compositions comprising polymers modified with N-alkyl-hydroxy groups comprising one or more carbon atoms. The compositions are useful for gene delivery, and exhibit broad-spectrum antiviral activity and low toxicity in vitro.

Therapeutic compositions comprising n-alkyl-hydroxy polymers

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Singapore, Singapore

Chuan Yang