Sunny Pharmtech Inc.

Corum Inc.

Chu-Yi Pang

Nai-Hsuan Hsu

Jien-Heh Tien

Chia-Jung Hsu

Ssu-Ching Wang

Chi-Jen Huang

Chiao-Yi Hsu

Ting-Wan Chen

Chien-Jen Wu

Peimin Lee

This invention discloses a method of making vitamin K1. The mentioned method of making vitamin K1 comprises performing a first one-pot synthesis with base catalyst, performing a first hydrolysis, performing a substitution, and performing a second one-pot synthesis without metal oxidant. The starting material of this invention is stable 2-methyl-1,4-naphthoquinone. Preferably, this invention provides a method of making vitamin K1 efficiently on simplifying the operation and decreasing the side-product. More preferably, without metal residue, the vitamin K1 of this invention is without metal residue and more safety for clinical application.

Method of making vitamin K1

The invention provides a method for inhibiting melanin formation composition by applying a glycine derivative, having a structure shown in the following general equation (I): wherein Rrepresents a C1&#x2dc;C4 alkyl group; Rrepresents a hydrogen atom or a methyl group; and n represents an integer of 1&#x2dc;6.

Glycine derivative capable of inhibiting melanin formation and composition using the same

The present invention provides a method for making 6-aminocaproic acid as an active pharmaceutical ingredient. The method comprises: performing a hydrolysis procedure to have &#x3b5;-caprolactam react with acid or base to generate a first reaction mixture, performing a modification procedure to have a solubility regulating agent reacts with 6-aminocaproic acid in the first reaction mixture to form a second reaction mixture including an aminocaproic acid intermediate, performing a separation procedure to have the intermediate separated from the second reaction mixture and performing a hydrogenation procedure to have the aminocaproic acid intermediate hydrogenated to form a 6-aminocaproic acid product.

Method of making 6-aminocaproic acid as active pharmaceutical ingredient

A process for synthesis of androstane 17-&#x3b2; carbothioic acid is provided. The process includes mixing an androstane 17-&#x3b2; carboxylic acid and a coupling reagent, and adding an alkanethioic acid to form an androstane 17-&#x3b2; carbothioic acid, wherein the androstane 17-&#x3b2; carbothioic acid has the formula (I): 

Process for synthesis of androstane 17-&#x3b2; carbothioic acid and relative compounds thereof

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Taipei, Taiwan

Chu-Yi Pang