Industrial Technology Research Institute

Yung Shin Pharm. Ind. Co., Ltd.

Anchen Laboratories, Inc.

Chrong-Shiong Hwang

On Lee

Jenn-Tsang Hwang

Yuan-Jang Tsai

Chih-Hung Chen

Chih-Peng Liu

Yen-Chun Chen

Chen-Yi Su

Tsan-Lin Hu

Chung-Niang Yao

Sheng-Chu Kuo

Che-Ming Teng

Hsin-Hsin Shen

Fang-Yu Lee

Lain-Tze Lee

Kuo-Kuei Huang

Ying-Chu Shih

Yi-Hsun Chen

Tsang-Miao Huang

Ting-Shou Chen

Ching-Huai Ko

Yu-Long Chang

Ling-Mei Wang

Jui-Wen Huang

Yow-Lone Chang

Kuei-Tai Lai

Chi-Ying Hung

Shing Mein Wu

Chiu Hsing Lin

Shing-Mein Wu

Chin-Yi Wu

Lain-tze Lee

A compound of formula (I) or a pharmaceutically acceptable salt thereof is provided. In formula (I), Ar is indazole, 5-isoquinoline, 6-isoquinoline, or their N-oxide. X is &#x2014;C(&#x2550;Z)&#x2014;, wherein Z is N&#x2014;CN, NH, NR, NCOR, NCONRR, NCO-aryl, S, or O. Y and J are independently H, alkyl, aryl, aminoalkyl, &#x2014;NH, &#x2014;CN, &#x2014;OH, &#x2014;O-alkyl, &#x2014;O-aryl, &#x2014;COOH, &#x2014;COOR, &#x2014;CONHR, &#x2014;CONHCH-aryl, &#x2014;CONRCH-aryl, &#x2014;NHCOR, halogen, halogened alkyl, -alkyl-OR, -alkyl-ONO, alkyl-ONO, &#x2014;OCOOR, &#x2014;O(C&#x2550;O)-aryl, &#x2014;CHROH, &#x2014;CHOH, &#x2014;CHO(C&#x2550;O)-aryl, &#x2014;CHO(C&#x2550;O)&#x2014;R, &#x2014;CHRO(C&#x2550;O)-aryl, &#x2014;CHRO(C&#x2550;O)&#x2014;R, unsaturated carboxylic ester, substituted alkynyl, &#x2014;NHSOR, &#x2014;SOR, &#x2014;SONHR, or &#x2014;SONRR, or Y and J bond together to form a carbocylic or aromatic ring, wherein Rand Rare independently H, substituted C1-C6 alkyl, substituted aryl, cycloalkyl, alkylaryl, -alkyl-NRR, &#x2014;S(O)-(alkyl-NRR). R, Rand Rare H, C1-C6 alkyl, cycloalkyl, aryl, alkylaryl, alkylheteroaryl, alkylheterocycle, wherein any one thereof is optionally substituted with one or more of OH, NO, or NRR. 

Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same

The invention provides compounds of Formula (I), pharmaceutical compositions and methods of synthesis thereof. 

GABA analogs, compositions and methods for manufacturing thereof

The invention is related to novel azulene-oxindole compounds having formula (I) shown below, wherein one of R, Rand Rrepresents a moiety of formula (II), each of Aand Aindependently is nitrogen, oxygen or sulfur, each of the others of R, R, R, R, R, R, R, R, R, R, R, R, R, and Ris as recited in the specification. The novel compound potentially inhibits multiple kinases and thus can be used to treat some disease like cancer or inflammatory. 

Azulene-oxindole compounds as multiple-kinase inhibitors and useful as anticancer agents

An oligopeptide comprises formulae (I) or (II)  the oligopeptide derivative thereof, and a pharmaceutical composition comprising the same are provided.

NAP derivatives

The present invention provides a neurodegenerative, non-human transgenic mammal whose cells contain a TrkA-hFc transgene for encoding at least a TrkA fusion protein and the use thereof.

Neurodegenerative non-human transgenic mammal expressing TrkA fusion protein

The present invention synthesizes a series of novel indole analogs of 1-benzyl-3-(5'-hydroxymethyl-2&#x2032;-furyl)indazole (YC-1), and their anti-platelet activity.

Synthesis of indole analogs of 1-benzyl-3-(5'-hydroxymethyl-2&#x2032;-furyl) indazole (YC-1) as anti-platelet agents

The present invention relates to a compound represented as formula (I):wherein

Compound and derivative of gabapentin

Growing community of inventors

Hsinchu, Taiwan

Chrong-Shiong Hwang