University of Minnesota

Northwestern University

Christy Lynn Haynes

Samuel Michael Egger

Joseph T Walsh, Jr

Richard P Van Duyne

Mathew R Glucksberg

Jonathan M Yuen

Olga Lyandres

Nilam C Shah

Katherine Rose Hurley

Karen E Peltier

Chanda Ranjit Yonzon

Douglas A Stuart

Ashish Datt

The present invention relates to mesoporous silica coated nanoparticles comprising a metal oxide nanoparticle core; and a mesoporous silica shell encapsulating metal oxide core; wherein said mesoporous silica shell and the metal oxide core are not in full contact. The nanoparticles of the invention are useful as diagnostic and therapeutic agents.

Mesoporous silica-coated nanoparticles

Silica particles, and methods of making and using silica particles are disclosed herein. In some embodiments, the silica particles are hollow, include an outer shell portion having a mesoporous structure, and have a pore volume of at least 4 cm/g. In some embodiments, the silica particles include an outer shell portion having a mesoporous structure forming a cavity, the silica particles have an average pore diameter of 3 to 100 nm, and at least a portion of the silica particles include one or more core nanoparticles within the cavity. Silica particles as disclosed herein can be useful in a wide variety of applications such as selective separations (e.g., gas separations or purifications) based on structure.

Porous silica having high pore volume and methods of making and using same

The present invention relates to biosensors, in particular to surface-enhanced Raman biosensors for detection of in vivo and ex vivo analytes. In particular, the present invention provides compositions and methods for the in vivo detection of analytes such as glucose.

Surface-enhanced raman nanobiosensor

Growing community of inventors

Minneapolis, MN, United States of America

Christy Lynn Haynes