Université´ D'aix-Marseille

University of London

Inserm (institut National De La Sante Et De La Recherche Medicale)

Assistance Publique Hopitaux De Marseille

Christos Chadjichristos

Françoise Dignat-George

Marcel Blot-Chabaud

Nathalie Bardin

Benjamin Guillet

Guillaume Hache

Aurélie Leroyer

Alexandrine Bertaud

Christoph Thiemermann

The present invention relates to the field of medicine and in particular to the diagnostic and treatment of fibrosis. More particularly, the invention relates to CD146 and uses thereof as a biomarker in the diagnosis of fibrosis and as a therapeutic target in the treatment of fibrosis. The invention also relates to compositions and methods of detecting predisposition to, of diagnosing, prognosing and/or monitoring fibrosis in a subject. It further relates to CD146 inhibitors, and to compositions comprising a CD146 inhibitor, for use in prevention or treatment of fibrosis in a subject, as well as to compositions, kits and uses thereof in a diagnostic or therapeutic context.

CD146 and uses thereof as a biomarker and as a therapeutic target in the diagnosis and treatment of fibrosis

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VILLERS SOUS SAINT LEU, France

Christos Chadjichristos