Impel Pharmaceuticals Inc.

Impel Neuropharma, Inc.

Christopher William Fuller

Craig Frederick Kohring

John D Hoekman

Alan Brunelle

Albert Kenneth Lavin

Scott Youmans

Stephen B Shrewsbury

Kelsey H Satterly

Scott B Youmans

A device for delivering a compound to the olfactory region of the nasal cavity includes an actuator body and a tip that removably couples to the actuator body. The actuator body comprises a propellant channel in fluid communication with a propellant canister. The tip comprises an exit channel, an inlet interface, one or more grooves, and an outlet orifice. The exit channel extends between a proximal end and a distal end of the tip. The inlet interface is positioned about a distal end of the exit channel, and the inlet interface couples to a compound container containing the compound. The grooves are positioned about the inlet interface and direct propellant from the propellant channel into the compound container, thereby agitating and entraining the compound in the compound container with the released propellant. The compound and the propellant then travel through the exit channel and out the outlet orifice.

Intranasal device with inlet interface

Embodiments relate to a single-use device for delivery of medication into a nasal cavity. In an embodiment, the device includes a propellant canister containing a propellant capable of propelling the compound to the nasal cavity. The propellant canister is displaceable between an unactuated position and an actuated position within the device. The device further includes an actuation element with an actuation lever configured to displace the propellant canister from the unactuated position to the actuated position. The device also includes a puncture element positioned to puncture the propellant canister, which causes the release of the propellant from the propellant canister. The device further includes a dose holding chamber containing a unit dose of the compound. The dose holding chamber is positioned such that propellant flows into the dose holding chamber and causes the compound to be propelled from the dose holding chamber to the nasal cavity of the user.

Single-use nasal delivery device

A nasal drug delivery device for delivering a plume derived from a propellant and a drug compound. The drug compound is in an intranasal dosage form in the form of powder, suspension, dispersion, or liquid. The propelled intranasal dosage form is deposited within the upper nasal cavity such as the olfactory region. The drug deposited within the olfactory region is delivered to the brain avoiding the blood-brain-barrier. Hydrofluoroalkane propellant from a pressurized canister is channeled to a diffuser and drug-containing channel where the intranasal dosage form is aerosolized. The aerosolized intranasal dosage form passes through a nozzle thus delivering a plume to the user's upper nasal cavity.

Nasal drug delivery device with detachable nozzle

A device for delivering a compound to the olfactory region of the nasal cavity includes an actuator body and a tip configured to removably couple to the actuator body. The actuator body comprises a propellant channel in fluid communication with a propellant canister. The tip comprises a tip stem, a dip tube, a delivery channel, one or more puncture members, and an outlet orifice. The tip stem receives a compound container containing the compound and the compound container moves between a sealed state and an unsealed state. The one or more puncture members are each configured to puncture the compound container when the compound container is in the unsealed state. Propellant released from the canister travels through the propellant channel and into the punctured compound container, thereby contacting the compound and propelling the compound through the delivery channel and out the outlet orifice.

Intranasal device with dip tube

A device for delivering a compound to the olfactory region of the nasal cavity includes an actuator body and a tip that removably couples to the actuator body. The actuator body includes a propellant channel in fluid communication with a propellant canister. The tip includes an exit channel, an inlet interface, one or more grooves, and an outlet orifice. The exit channel extends between a proximal end and a distal end of the tip. The inlet interface is positioned about a distal end of the exit channel, and the inlet interface couples to a compound container containing the compound. The grooves are positioned about the inlet interface and direct propellant from the propellant channel into the compound container, thereby agitating and entraining the compound in the compound container with the released propellant. The compound and the propellant then travel through the exit channel and out the outlet orifice.

A delivery device for a compound including: a housing, vial holding a compound; and a source of propellant, wherein the housing provides an inlet and an outlet for the vial, wherein the inlet is in fluid communication with the source of propellant and is directed against the in-line nasal delivery device compound and the outlet allows for delivery of the compound.

In-line nasal delivery device

A unit dose container for the containment of an intranasal formulation for use with the POD device.

Medical unit dose container

Methods are provided for acutely treating migraine headache with or without aura. The methods comprise administering to a subject with migraine headache an effective dose of a liquid pharmaceutical composition comprising dihydroergotamine (DHE) or a salt thereof, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma DHE concentration (C) of at least 750 pg/ml, (b) with a mean time to C(T) of DHE of less than 45 minutes, and (c) a mean plasma AUCof DHE of at least 2500 pg*hr/ml. Also provided are kits for acutely treating migraine with or without aura in which a liquid pharmaceutical composition comprising DHE or DHE salt is contained within a sealed vial that is attachable to a precision intranasal olfactory delivery device packaged therewith.

Growing community of inventors

Seattle, WA, United States of America

Christopher William Fuller