Pfizer Corporation

University of Delaware

Bioduro, LLC

Christopher William Am Ende

Martin Youngjin Pettersson

Douglas Scott Johnson

Chakrapani Subramanyam

Christopher John O'Donnell

Michael Eric Green

Tuan Phong Tran

Cory Michael Stiff

Patrick Robert Verhoest

Antonia Friederike Stepan

Gregory Wayne Kauffman

Nandini Chaturbhai Patel

Hua Zhou

John Michael Humphrey

Christopher John O'donnell

Benjamin Adam Fish

Patrick Bradley Mullins

Thayalan Navaratnam

Joseph M Fox

Yinzhi Fang

Yixin Xie

Paramita Mukherjee

Rongqiang Liu

Tianjing Deng

William Lambert

Chuanqi Wang

Subham Mahapatra

Danica Antonia Rankic

Disclosed herein are mono- and di-substituted tetrazines and methods of their preparation and converting an oxetanyl ester to a thio-substituted tetrazine, which is then converted to a mono-substituted tetrazine, a di-substituted tetrazine, or a vinylether disubstituted tetrazine.

Reagents and methods for tetrazine synthesis

Disclosed herein are compounds of formula Ar&#x2014;N(SOF), wherein Ar is selected from an optionally substituted aryl, an optionally substituted five-membered heteroaryl, or an optionally substituted six-membered heteroaryl. Also disclosed are methods of synthesizing the above compounds by reacting a compound of formula Ar&#x2014;NH&#x2014;Rwith MN(SOF). 

Reagents for fluorosulfating alcohols or amines

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I wherein X, R, R, R, R, R, R, R, R, R, R, R, and y are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Cyclopropabenzofuranyl pyridopyrazinediones

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Bicyclic pyridinones

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Mystic, CT, United States of America

Christopher William Am Ende