Bayer Intellectual Property Gmbh

Bayer Schering Pharma Ag

Schering Aktiengessellschaft

Christopher West

Shendong Yuan

Judi Bryant

Raju Mohan

Brad Owen Buckman

Imadul Islam

Karen B May

Kumar Emayan

Gary Bruce Phillips

Monica J Kochanny

Bin Ye

Martin Krueger

Marc Adler

Stefan Baeurle

Yuo-Ling Chou

Wheeseong Lee

Seock-Kyu Khim

Paul Hrvatin

Michael Mamounas

Janet Meurer Ogden

Victor Selchau

This invention provides novel dihydropyridine derivatives of the formula I having protein tyrosine kinase inhibitory activity, to process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions.

Dihydropyridine derivatives as useful as protein kinase inhibitors

Compounds of the following formula (I), for example: wherein R, R, R, and Rare described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

Plasma carboxypeptidase B inhibitors

Compounds of the following formula (I), for example: (1), wherein R, R, R, and Rare described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein. 

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El Sobrante, CA, United States of America

Christopher West