Michigan State University

Christopher Waters

Martin F Semmelhack

Matthew Neiditch

Michael Maiden

Karthik Sambanthamoorthy

The present disclosure provides, among other things, compositions and methods useful for inhibiting biofilm-forming bacteria. For example, the compositions and methods described herein can be used to inhibit the proliferation, viability, and/or biofilm-forming activity, of biofilm-forming bacteria.

Compositions and methods for inhibiting biofilm-forming bacteria

The various embodiments relate to a compound comprising: wherein R, R, R, R, R, R, R, R, R, R, R, and Rare each independently hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclyl, alkoxy, aryloxy, heteroaryloxy, alkoxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, alkylsulfonyl, arylsulfonyl, aminosulfonyl, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, acyl, acylamino, amino, alkylamino, dialkylamino, arylamino, carboxylate (&#x2014;COH), cyano, nitro, &#x2014;CONH2, heteroarylamino, oxime, alkyloxime, aryloxime, amino-oxime or halogen when A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, and Q are carbon, and X is O, NR (where R is hydrogen, alkyl, aryl or acyl), S, SO (sulfoxide), SO(sulfone), or C(R)(where R=H, alkyl, aryl, alkenyl, alkynyl, or acyl); or wherein R, R, R, R, R, R, R, R, R, R, R, and Rare each independently hydrogen or hydroxyl when A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, and Q are each independently nitrogen, and compositions, combinations, pharmaceutically acceptable salts, esters, and prodrugs thereof. The invention also relates to methods of using such compounds and compositions.

Growing community of inventors

East Lansing, MI, United States of America

Christopher Waters