Astrazeneca Ab

University of Dundee

Neomed Institute

Christopher Walpole

William Brown

Niklas Plobeck

Hua Yang

Andrew Griffin

Zhongyong Wei

Daniel Pagé

Ziping Liu

Paul Jones

Maxime Tremblay

Yun-Xing Cheng

Miroslaw Jerzy Tomaszewski

Ian Gilbert

Susan Davis

Neil Norcross

Laura Cleghorn

Thomas Hudzik

Beatriz Baragana

Chimed Jansen

Barbara Forte

Sanjay Srivastava

Regis Dolaine

Zhong-yong Wei

Zena Qadoumi

Gennady Smagin

Carla Maciag

Daniel Page

The present invention relates to a novel class of chromene-2-carboxamide compounds inhibitors of general formula I wherein R, R, R, R, R, R, R, Rand X are as defined herein, to their use in medicine, and their use as anti-infective agents in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.

Anti-infective agents

Compounds of Formula (I) or pharmaceutically acceptable salts thereof; wherein R, R, R, and Rare as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain. 

Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof

Compounds of general formula: as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain, depression and anxiety.

Diarylmethyl piperazine derivatives, preparations thereof and uses thereof

The invention relates to at least one compound of general formula I wherein Ris phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, or pyridine N-oxide, where each Rphenyl and Rheteroaromatic ring may optionally and independently be substituted by 1, 2 or 3 substituents selected from CF, methyl, iodo, bromo, fluoro, and chloro; Ris independently selected from ethyl and isopropyl;Ris hydrogen or fluoro; Ris &#x2014;NHor &#x2014;NHSOR; and Ris hydrogen, &#x2014;CF, or C-Calkyl, or pharmaceutically acceptable salts thereof; at least one process for making at least one compound in accordance with Formula I; at least one method for treating at least one &#x3b4; receptor associated condition with at least one compound in accordance with Formula I; and at least one pharmaceutical composition comprising at least one compound in accordance with Formula I.

4-(phenyl-piperazinyl-methyl)benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders

Compounds of general formula: wherein R, Rand Rare as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders

The invention relates to at least one compound of general formula I wherein Ris phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, or pyridine N-oxide, where each Rphenyl and Rheteroaromatic ring may optionally and independently be substituted by 1, 2 or 3 substituents selected from CF, methyl, iodo, bromo, fluoro, and chloro; Ris independently selected from ethyl and isopropyl;

Compounds

Compounds of formula I or pharmaceutically acceptable salts thereof: wherein R, R, Rand Rare as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Therapeutic compounds

Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein R, R, R, R, R, and G are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Compounds, compositions containing them, preparation thereof and uses thereof I

Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R, R, R, Rand Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain. 

Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain. 

Compounds of formula (I) wherein R, R, Z, R, R, Ar, X and Y are as defined in the specification as well as salts and pharmaceutical compositions including the compounds were prepared. These compounds are useful in therapy, in particular in the management of pain. 

Compounds of general formula: wherein Rand Rare as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders

Compounds of formula I or pharmaceutically acceptable salts thereof Formula (I) wherein Ar, R, R, R, R, Rand X are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain 

Azaindole derivatives, preparations thereof, uses thereof and compositions containing them

Compounds of general formula (I) wherein R, Rand Rare as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain 

4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain of gastrointestinal disorders

Compounds of formula (I) or pharmaceutically acceptable salts thereof: Formula (I) wherein R, R, RF, RFand Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain 

Growing community of inventors

Montreal, Canada

Christopher Walpole