Waters Technologies Corporation

Koninklijke Philips Corporation N.v.

Christopher Walden

Sean Eric Anderson

Timothy M Raymond

Virginia Higley

Paul Aelen

Tyler Douglas Smith

Daniel Calvert Canfield

Michael Knipfer

Ahmed Fouad Said Reda

Mark Payne

Tyler Smith

John Olson

Mark Dominguez

Steve Frankovich

Daniel Burch

Daniel William Jordan, Iii

Dan Canfield

Steven Joseph Frankovich

Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, an actuation mechanism having a piston located within a bored structure surrounding the piston, the actuation mechanism configured to open and close at least one of the plurality of conduits in a controlled manner where the piston and the bored structure have a tight tolerance configured to create a fluid tight seal, and a common outlet port configured to receive the fluid composition.

Gradient proportioning valve

Described is a check valve having a valve housing, a valve seat, a ball and a spherical loading element. The valve seat is disposed proximate to a first end of the bore. The ball is disposed in the bore and is movable between a closed position in which the ball is received against the valve seat and prevents a flow of fluid through the bore and an open position in which the ball is displaced from the valve seat and allows fluid to flow through the bore. The spherical loading element is disposed in the bore and is movable between the ball and the second end of the bore. The spherical loading element applies a supplemental force to move the ball against the valve seat during closing of the check valve. The check valve provides a low and predictable cracking pressure which does not vary significantly between similarly manufactured valves.

Check valve having a spherical loading element

Disclosed is a gradient proportioning valve for use in liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and an active fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold. Liquid chromatography systems and methods are further disclosed.

Active dampening gradient proportioning valve

Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of fluid conduits internal to the manifold, each of the plurality of fluid conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of fluid conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of fluid conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and a passive fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold where at least one of the plurality of fluid conduits is compliant.

Passive dampening gradient proportioning valve

A cardio-pulmonary compression system includes a compression device (), a supporting mechanism () coupled to the compression device and a feedback sensor () configured to measure interactions between a patient and the compression device. A control unit () is configured to receive input from the feedback sensor and adjust operating parameters of the compression system to meet a target parameter during operation of the compression device.

Compensation for deflection in an automated cardiopulmonary compression device

A cardio-pulmonary compression board includes a board () configured for a patient. A leg () is pivotally connected to the board, and the leg includes a free end portion having a mechanical feature () configured to be received in a compression device to adjustably secure the compression device at a distance from the board in an operational position. A locking mechanism () is configured to releasably maintain the leg in the operational position, which is transverse to a plane of the board.

Cardiopulmonary compression device receiving flip-up legs

A cardio-pulmonary compression device includes a motor () having a rotating portion, and a ball nut () mounted on the rotating portion and configured to rotate with the rotating portion. A ball screw () is received in the ball nut such that rotation on the ball nut advances and/or retracts the ball screw in accordance with a direction of the motor. A pad assembly () is coupled to an end portion of the ball screw such that longitudinal motion of the ball screw imparts a compression cycle to a patient.

Growing community of inventors

Framingham, MA, United States of America

Christopher Walden