Pneuma Respiratory, Inc.

United States Surgical Corporation

Other

Tyco Healthcare Group LP

Christopher W Maurer

John Hilbert Hebrank

Charles Eric Hunter

Louis Thomas Germinario

Chengjie Li

Jack C Hunter

Jeffrey J Blewett

Corbett W Stone

Randolph F Lehn

Graham W Bryan

Robert C Savage

Kamran Aflatoon

Dale F Oexmann

John F Klinger

Francis X Kaczynski

Kenneth P Holmes

Matthew W Lueck

Shane B Stanford

Kevin R Beto

John H Hebrank

Michael E Lindsey

Michael A Pier

David S Shafer

A nasal droplet delivery device and related methods for delivering precise and repeatable dosages to a subject via the nasal passageways and sinus cavities.

Nasal drug delivery apparatus and methods of use

A droplet delivery device with a small volume drug ampoule and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device is configured to facilitate the ejection of small, e.g., single use, volumes of a therapeutic agent. The droplet delivery device includes a housing, a mouthpiece, a small volume drug ampoule, an ejector mechanism, and at least one differential pressure sensor. The delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 &#x3bc;m, so as to target the pulmonary system of the user. The small volume drug ampoule may include a reservoir which comprises an internal flexible membrane separating two internal volumes, a first background pressure fluid volume and a second drug volume.

Electronic breath actuated in-line droplet delivery device with small volume ampoule and methods of use

An in-line droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The in-line droplet delivery device includes a housing, a mouthpiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The in-line droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The in-line droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 &#x3bc;m, so as to target the pulmonary system of the user. the droplet delivery device is configured in an in-line orientation in that the housing, its internal components, and various device components (e.g., the mouthpiece, air inlet flow element, etc.) are orientated in a substantially in-line or parallel configuration (e.g., along the airflow path) so as to form a small, hand-held device.

Electronic breath actuated in-line droplet delivery device and methods of use

A nasal droplet delivery device and related methods for delivering precise and repeatable dosages to a subject via the nasal passageways and sinus cavities is disclosed. The droplet delivery device includes a housing, a nosepiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically actuated by the user when the differential pressure sensor senses a predetermined pressure change within the nosepiece. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter of greater than about 6 microns, preferably greater than about 10 micron, so as to target the nasal passageways and sinus cavities of the user.

A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 &#x3bc;m, so as to target the pulmonary system of the user.

Methods for generating and delivering droplets to the pulmonary system using a droplet delivery device

Droplet delivery device for delivery of fluids to the pulmonary system and methods of use

An fusion cage having a longitudinal element and two planar bendable expansion arms slideably captured in a track on opposing sides, the expansion arms expandable from a pre-implantation position adjacent to the longitudinal element to a deployed position bounding an area around the longitudinal element in which bone graft material may be packed and retained after implantation into the intervertebral space. The longitudinal element is eliminated in favor of front and back lateral tracks in which the opposing ends of the expansion arms are slideably received so as to allow expansion of the bounded areas in both a lateral and anterior-posterior direction by sliding within the channels. Expansion of the area within the bendable members may be accomplished by rotation of leaves to which the bendable members are rigidly and slideably affixed.

Laterally expandable interbody fusion cage

A first vehicle includes a first device for receiving global positioning system (GPS) signals, generating at least one of a first time, position and velocity signal based on the received GPS signals, generating at least one of a second time, position and velocity signal based upon the motion of the first vehicle, comparing the first and second signals, generating a corrected first vehicle signal, and transmitting the corrected first vehicle signal. A second vehicle includes a second device for receiving GPS signals, generating at least one of a third time, position and velocity based on the received GPS signals, generating at least one of a fourth time, position and velocity based on the motion of the second vehicle, comparing the third and fourth signals, generating a corrected second vehicle signal, receiving the corrected first signal, and calculating from the corrected first and second vehicle signals the likelihood that the positions of the first and second vehicles will coincide at some time.

Vehicle collision warning system

An apparatus and method for the thermal treatment of tissue, e.g., prostatic tissue, with RF energy is disclosed. The apparatus includes a handle dimensioned to be grasped with a single hand of a surgeon, an elongated portion extending distally from the handle and defining a longitudinal axis, at least one electrode extending within the elongated portion and movable between a non-deployed position and a fully deployed position, and a trigger mechanism associated with the handle and having a trigger operatively connected to the one electrode. The trigger is movable to selectively and incrementally move the one electrode between the non-deployed position and the fully deployed position. A ratchet mechanism permits movement of the trigger in one direction corresponding to movement of the one electrode toward the fully deployed position while preventing movement of the trigger in a second direction. The elongated portion of the apparatus may be rotatable about the longitudinal axis to reposition the one electrode.

Apparatus and method for thermal treatment of body tissue

An apparatus for the radio-frequency (RF) thermal treatment of tissue, particularly, prostatic tissue is intended for use in conjunction with a conventional endoscope. The apparatus includes an elongate member having at least one passageway extending at least partially along its length, a delivery tube disposed within the passageway and having a memory portion comprised of a shape memory material, and being moveable within the passageway to extend the memory portion from the elongate member to permit the memory portion to assume a normal unstressed curved configuration, an electromagnetic probe disposed within the delivery tube and moveable within the delivery tube to extend a probe end portion beyond the delivery tube and within tissue. The electromagnetic probe has sufficient flexibility to follow the curved path defined by the memory portion of the delivery tube. The elongate member of the apparatus may further include a channel dimensioned to receive a conventional endoscope. Proximally positioned actuators permit selective movement of the delivery tube and electromagnetic probe. A system for thermal treatment of tissue includes a thermal treatment apparatus and an endoscope which is positioned within a working channel of the apparatus.

Apparatus for thermal treatment of tissue

An auxiliary electromagnetic thermal treatment apparatus for use with an endoscope to provide the endoscope with electromagnetic thermal treatment capabilities is provided. The auxiliary apparatus includes a handle portion and an elongate portion connected to the handle portion and dimensioned to be at least partially inserted within a working channel of an endoscope. The elongate portion includes at least one delivery tube having a memory portion comprised of a shape memory material and defining a normally unstressed curved configuration. The one delivery tube is longitudinally moveable relative to the handle portion to extend the memory portion beyond the working channel of the endoscope such that the memory portion assumes the normal unstressed curved configuration thereof. An electromagnetic probe is disposed within the delivery tube and is longitudinally moveable relative to the delivery tube to extend a probe end portion thereof beyond the delivery tube and within tissue. The electromagnetic probe is adapted to follow the curved configuration of the memory portion of the delivery tube for deployment at an angularly oriented relation with respect to the endoscope. A first actuator is mounted to the handle portion and operatively connected to the delivery tube. A second actuator is also mounted to the handle portion and is operatively connected to the electromagnetic probe. The actuator is moveable to extend the probe end portion beyond the delivery tube. The present disclosure is also directed to a combination of an endoscope and an auxiliary thermal treatment device. A method for thermally treating tissue is also disclosed.

Growing community of inventors

Irvine, CA, United States of America

Christopher W Maurer