Novartis Ag

Christopher Turchik Jagoe

Richard William Versace

Kenneth Walter Bair

Sompong Wattanasin

Frederick Ray Kinder, Jr

Peter Lassota

The present invention relates to methods for treating multidrug resistant cells, preferably multidrug resistant cancer cells with discodermolide. Discodermolide is found to be effective in limiting the growth of otherwise growth unregulated cells having tubulin mutations and in promoting phosphorylation of the oncogene RAF-1.

Method for treating cells resistant to antineoplastic agents

The present invention relates to certain substituted caprolactam compounds, pharmaceutical compositions containing said compounds, the use of said compounds in treating tumors and to a process for making said compounds.

Use of certain substituted caprolactams in treating tumors

The present invention relates to certain substituted caprolactam compounds of formula (I), where R,is (C,)alkyl or (C,)cycloalkyl; R,hydrogen or (C,)alkyl; X is (C,)alkynylene; (C,)alkynylene; m is 0 or 1; and R,is (C,)cycloalkyl; or an aromatic ring system selected from (II, III, IV and V), where R,is hydrogen, chloro, or methoxy; R,is hydrogen, chloro, (C,)alkyl or (C,)alkoxy, and Z is oxygen, sulfur, N&mdash;H, or N&mdash;CH,; or a pharmaceutically acceptable acid addition salt thereof, where possible, pharmaceutical compositions containing said compounds, the use of said compounds in treating tumors and to a process for making said compounds.

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Chatham, NJ, United States of America

Christopher Turchik Jagoe