Wyeth

Bioventus, LLC

Christopher Todd Brown

Christopher G Wilson

John Martin Wozney

Howard Seeherman

Robert Vincent Martinez

Stephen Berasi

Valerie Calabro

Michael John Cain

Zong Sean Juo

Eric Vanderploeg

John A Kambouris

Jimin Zhang

Wei Liu

Stephane Olland

Zhijian Lu

Paul John Yaworsky

Emily Sheng-Ming Shen

Z Sean Juo

Stephen Peter Berasi

Valerie Perrine Calabro

Robert Vincent Paul Martinez

Howard Joel Seeherman

Valarie Perrine Calabro

Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.

Systems and methods for improved delivery of osteoinductive molecules in bone repair

The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.

Designer osteogenic proteins

Systems and methods for preparing osteoinductive synthetic bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.

Matrix for enhanced delivery of osteoinductive molecules in bone repair

Osteogenic proteins

Members of the TGF-&#x3b2; superfamily and peptide fragments based on member proteins are employed to purify solutions containing member proteins or as therapeutics.

Finger-1 peptide analogs of the TGF-&#x3b2; superfamily

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Chelmsford, MA, United States of America

Christopher Todd Brown