Chiroscience, Ltd.

Genzyme Corporation

Celsis International, Plc

Biotal Ltd.

Chiros Ltd.

Christopher T Evans

Stanley M Roberts

Raymond McCague

Richard Anthony Wisdom

Stephen Philip Mann

Nicholas Peter Foote

Peter Leonard Grant

Stephen John Taylor

Nicholas David Tyrrell

Robert C Charley

David Parfitt

Michael Noble

Rosemary Mackeith

Karoline Shoberu

Cyclopentenes

Lactams of 1-amino-3-carboxylic acid cyclic compounds are provided in enantiomeric form, together with an enantiomer of the corresponding ring-opened amino-acid or ester, by reaction of the racemic lactam with a novel lactamase. The products are useful in the synthesis of chiral carbocyclic nucleotides. The enantiomer is preferably 2-azabicyclo�2.2.1!hept-5-en-3-one.

Preparation of biologically active compounds from substantially pure

Enantiomeric glutarimides such as aminoglutethimide and rogletimide are prepared by cyclisation of a corresponding ester-nitrile which is a good substrate for biotransformation with an enantiospecific esterase.

Chiral compounds and their resolution synthesis using enantioselective

Method and apparatus for the analysis of biological material

Crystallization process for preparing glycerophosphocholine

Phosphoenolpyruvate carboxylase (PEPC) characterized by a specific activity of at least 40 units/mg; and/or by no more than 50% loss of activity after 60 days in 167 mM Tricine/HCl buffer, pH 8.0, and 15 mM MgCl.sub.2 ; and/or, at pH 6.5, an activity of at least 40% relative to the activity at optimum pH is disclosed. Such enzymatic activity can be obtained from serine pathway methylotrophs such as Hyphomicorbium, and is very suitable for use in measuring bicarbonate in biological samples.

Bicarbonate assay and phosphoenolpyruvate carboxylase enzyme from

Lactams of 1-amino-3-carboxylic acid cyclic compounds are produced in enantiomeric form, together with an enantiomer of the corresponding ring-opened amino-acid or ester, by reaction of the racemic lactam with a novel lactamase. The products are useful in the synthesis of chiral carbocyclic nucleotides. The enantiomer is preferrably 2-azabicyclo(2.2.1)hept-5-en-3-one. It is desirable to isolate the enantiomer comprising predominantly the (+) enantiomer and a residual amount of the (-) enantiomer, wherein the (+) enantiomer is present in an enantiomeric excess of at least about 88% over the (-) enantiomer or the enantiomer comprising predominantly the (-) enantiomer and a residual amount of the (+) enantiomer, wherein the (-) enantiomer is present in an enantiomeric excess of at least about 98% over the (+) enantiomer.

Substantially pure enantieners of 2-azabicyclo(2.2.1)hept-5-en-3-one

Formulation for treating silage containing .beta.-1,4-xylanase and

Lactams of 1-amino-3-carboxylic acid cyclic compounds are produced in enantiomeric form, together with an enantiomer of the corresponding ring-opened amino-acid or ester, by reaction of the racemic lactam with a novel lactamase. The products are useful in the synthesis of chiral carbocyclic nucleotides.

Process for preparing a single enantiomer of a lactam using lactamase

Growing community of inventors

Heydon, United Kingdom

Christopher T Evans