Harvard College

Christopher T Calderone

David R Liu

Zev J Gartner

Matthew William Kanan

Daniel M Rosenbaum

Xiaoyu Li

Jeffrey B Doyon

Matthew W Kanan

Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.

Evolving new molecular function

The present invention provides methods and compositions for performing multi-step nucleic acid mediated synthesis of a highly diverse collection of molecules, for example, small molecules and polymers. In the method, in at least two steps, multiple reaction intermediates and/or products are produced in the same step by different chemical reactions.

Iterated branching reaction pathways via nucleic acid-mediated chemistry

Growing community of inventors

Boston, MA, United States of America

Christopher T Calderone