Biota Europe Limited

Christopher Steele

John Atherall

Lloyd George Czaplewski

David John Haydon

Dale Mitchell

Nicholas Palmer

Tamara Ladduwahetty

David Wyn Watson

Gary Robert William Pitt

Ian Collins

Laura Andrau

David Davies

James T Palmer

Lorraine Claire Axford

Edward Malcolm Tyndall

Christopher James Lunnis

Daniel A Offermann

Michael Blair

The present invention provides a compound of the following formula and salts thereof: Also provided is the use of these compounds as antibacterials, compositions comprising them and processes for their manufacture.

Antibacterial compounds

Compounds of formula (I) have antibacterial activity: wherein: m is 0 or 1; Q is hydrogen or cyclopropyl; Alk is an optionally substituted, divalent C-Calkylene, alkenylene or alkynylene radical which may contain an ether (&#x2014;O&#x2014;), thioether (&#x2014;S&#x2014;) or amino (&#x2014;NR)&#x2014; link, wherein R is hydrogen, &#x2014;CN or C-Calkyl; X is &#x2014;C(&#x2550;O)NR&#x2014;, &#x2014;S(O)NR&#x2014;, &#x2014;C(&#x2550;O)O&#x2014; or &#x2014;S(&#x2550;O)O&#x2014; wherein Ris hydrogen, optionally substituted C-Calkyl, C-Calkenyl, C-Calkynyl, -Cyc, or &#x2014;(C-Calkyl)-Cyc wherein Cyc is optionally substituted monocyclic carbocyclic or heterocyclic having 3-7 ring atoms; Z is N; Rand Rare as defined in the description.

Antibacterial compositions

Compounds of formula (I) have antibacterial activity: wherein: m is 0 or 1; Q is hydrogen or cyclopropyl; Alk is an optionally substituted, divalent C-Calkylene, alkenylene or alkynylene radical which may contain an ether (&#x2014;O&#x2014;), thioether (&#x2014;S&#x2014;) or amino (&#x2014;NR)&#x2014; link, wherein R is hydrogen, &#x2014;CN or C-Calkyl; X is &#x2014;C(&#x2550;O)NR&#x2014;, &#x2014;S(O)NR&#x2014;, &#x2014;C(&#x2550;O)O&#x2014; or &#x2014;S(&#x2550;O)O&#x2014; wherein Ris hydrogen, optionally substituted C-Calkyl, C-Calkenyl, C-Calkynyl, -Cyc, or &#x2014;(C-Calkyl)-Cyc wherein Cyc is optionally substituted monocyclic carbocyclic or heterocyclic having 3-7 ring atoms; Z is N or CH, or CF; Rand Rare as defined in the description.

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Essex, United Kingdom

Christopher Steele