The Invention Science Fund I LLC

Dentigenix Inc.

Christopher Somogyi

Lowell L Wood, Jr

Clarence T Tegreene

Edward K Y Jung

Jordin T Kare

Eric Leuthardt

Philip Andrew Eckhoff

Mahalaxmi Gita Bangera

Erez Lieberman

Kevin Michael Esvelt

Brett M Bethke

Dario G Amodei

Jeremiah James Zartman

Xiaoyan Robert Bao

Anna Bershteyn

Kyle B Gustafson

William Michael Kaminsky

Lily Yvonne Kim

Ankur Moitra

Bruce Rutherford

Clinton White

Erick Rabins

Devices, methods, and systems are described for administration to at least one biological tissue of at least one device including at least one altered microorganism. In an embodiment, the altered microorganism includes at least one nucleic acid construct encoding at least one therapeutic agent.

Device including altered microorganisms, and methods and systems of use

The invention provides methods, apparatus and kits for regenerating dental tissue in vivo that are useful for treating a variety of dental conditions, exemplified by treatment of caries. The invention uses tissue scaffold wafers, preferably made of PGA, PLLA, PDLLA or PLGA dimensioned to fit into a hole of corresponding sized drilled into the tooth of subject to expose dental pulp in vivo. In certain embodiments the tissue scaffold wafer further comprises calcium phosphate and fluoride. The tissue scaffold wafer may be secured into the hole with a hydrogel, a cement or other suitable material. Either the wafer or the hydrogel or both contain a morphogenic agent, such as a member encoded by the TGF-&#x3b2; supergene family, that promotes regeneration and differentiation of healthy dental tissue in vivo, which in turn leads to remineralization of dentin and enamel. The tissue scaffold may further include an antibiotic or anti-inflammatory agent.

Methods for treating dental conditions using tissue scaffolds

Growing community of inventors

Woodinville, WA, United States of America

Christopher Somogyi