May & Baker, Ltd.

Rhone Poulenc Rorer

Rhone-poulenc Rorer S.a.

Christopher Smith

Neil Victor Harris

Iain M McLay

Clive McCarthy

Peter Charles Astles

Barry Porter

Frank Halley

Andrew David Morley

Garry Fenton

Roger J Walsh

Michael J Ashton

David J Lythgoe

David Riddell

Keith A Stuttle

Donald I Dron

Andrew W Bridge

Andrew Paul Van Sickle

Christopher G Newton

Tahir Majid

Andrew Bridge

Martyn Foster

Alan Roach

Trevor Parker

Ian Michael McFarlane

Robert K Chambers

Mark Francis Harper

Roger John Aitchison Walsh

Richard Alan Lewis

Malcolm P Toft

Devnandan Chatterjee

Peter J Warren

Substituted phenyl compounds

This invention is directed to compounds of formula I ##STR1## wherein R.sup.1 is CN, CH.sub.2 CN, CH.dbd.CHCN, CHO, or CH.dbd.CHCO.sub.2 H;

Substituted phenyl compounds with a substituent having a thienyl ring

Substituted phenyl compounds with a substituent having A

Imidazole derivatives of the formula: ##STR1## are described wherein R.sup.1 represents halogen, alkyl or alkoxy, n is 0 to 5, R.sup.2 represents hydrogen or alkyl, R.sup.3 represents hydrogen or alkyl optionally substituted by halogen, hydroxy, acyloxy, alkoxy, hydroxyalkoxy, acyloxyalkoxy, or by optionally substituted phenyl, or the groups R.sup.3 and the carbon atom to which they are attached together form a cycloalkane or cycloalkene group. They are pharmaceutically useful as antiatherosclerotic agents.

Imidazoles useful as antiatherosclerotic agents

Therapeutically useful isoquinolinone derivatives of the formula A--X--R.sup.3, wherein A represents a group of the formula: ##STR1## wherein R.sup.1 and R.sup.2 represents cycloalkyl, alkyl, alkenyl or alkynyl optionally substituted by halogen or cycloalkyl, or represents optionally substituted aryl or heteroaryl, R.sup.4 represents hydrogen, halogen, optionally substituted alkyl, alkenyl or alkynyl, optionally substituted aryl or heteroaryl, or a group R.sup.6 O-- wherein R.sup.6 represents alkyl, aryl or arylalkyl, X represents ethylene or vinylene, R.sup.3 represents a group of the formula:

Isoquinolinones

Therapeutically useful pyrrolo[2,1-a]phthalazine derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 represent cycloalkyl, optionally substituted alkyl, alkenyl, alkynyl, aryl or heteroaryl, X represents ethylene or vinylene, R.sup.3 represents a group of the formula:

Pyrrolophthalazines

There is described a process for the preparation of therapeutically useful pristinamycin II.sub.B sulphone derivatives. Also disclosed are compounds of general formula (I) in which n is equal to 2 in the form of their B isomers, and certain novel compounds of general formula (I) in which n is equal to 2. ##STR1##

Pristinamycin process

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Dagenham, United Kingdom

Christopher Smith