Other

Glt Acquisition Corp.

Christopher Slawinski

Roxanne E Abul-Haj

Alan Abul-Haj

Kevin H Hazen

Benjamin Mbouombouo

Alodeep Sanyal

Timothy Lewis Ruchti

Thomas B Blank

Kevin Hazen

Stephen L Monfre

Timothy Stippick

Sedar R Brown

The invention comprises a method and apparatus for selecting optical pathways sampling a common tissue position, such as a lateral mean range in the dermis, of a person for analysis in a noninvasive analyte property determination system, comprising the steps of: probing skin with a range of illumination zone-to-detection zone distances with at least two wavelength ranges, which optionally overlap, and selecting, using a metric, illumination zone-to-detection zone distances having mean optical pathways probing the common tissue layer, such as without the mean optical pathways entering the subcutaneous fat layer of the person. Optionally, the skin tissue layers are modulated and/or treated via tissue displacement before and/or during data collection.

Sample position resolved noninvasive glucose concentration determination analyzer apparatus and method of use thereof

The invention comprises a method and apparatus for sampling a common tissue volume and/or a common skin layer skin of a person as a part of noninvasively determining an analyte property with an analyzer including: a set of detectors at least partially embedded in a probe housing, the probe housing comprising a sample side surface, the detectors including a first and second range of detection zones of differing radial distances from a first illumination zone and second illumination zone, respectively coupled to separate sources, with surface paths between the sources and detectors overlapping a common skin area during use.

Common sample depth/zone noninvasive glucose concentration determination analyzer apparatus and method of use thereof

The invention comprises a method and apparatus for sampling optical pathways having a common tissue depth, such as a maximum mean depth of penetration in the dermis, with a common sample position of a person for analysis in a noninvasive analyte property determination system, comprising the steps of: probing skin with a range of illumination zone-to-detection zone distances with at least two wavelength ranges and detecting, using a set of detectors, illumination zone-to-detection zone distances having mean optical pathways probing the common tissue layer, such as without the mean optical pathways entering the subcutaneous fat layer of the person. Optionally, the skin tissue layers are modulated and/or treated via tissue displacement before and/or during data collection. Optionally, given illumination zone-to-detection zone distances are dynamically selected based upon a measure of state of the skin of the person.

Common depth and sample position noninvasive glucose concentration determination analyzer apparatus and method of use thereof

The invention comprises a method and apparatus for sampling skin of a person as a part of noninvasive analyte property determination system, comprising the steps of: providing an analyzer, comprising: sources and at least three detectors at least partially embedded in a probe housing, the probe housing comprising a sample side surface, the detectors including: a range of differing radial distances from a first illumination zone; repetitively illuminating an illumination zone of the skin with photons in a range of 1200 to 2500 nm; detecting portions of the first photons with the at least three detectors; and using signals from the at least three detectors and a metric, respectively classifying the skin into a first, second, and third tissue state, the radial distances of the at least three detectors differing from each other by greater than ten percent.

Tissue state classifier for noninvasive glucose concentration determination analyzer apparatus and method of use thereof

The invention comprises an applied force-optic analyzer used to determine a sample constituent concentration, a physical measure of the sample, and/or a state of the sample. The analyzer comprises: an electro-mechanical transducer affixed to skin of a subject; a controller, the controller providing a voltage waveform to the electro-mechanical transducer driving displacement of the skin and inducing a pressure wave into the skin; and a spectrometer interfaced to a sample site of the skin, the spectrometer comprising a set of sources and a set of detectors, where the controller is configured to collect signal from the set of detectors as a function of timing of the voltage waveform and apply a calibration model to the signal to determine the analyte concentration.

Noninvasive applied force / optical glucose concentration determination analyzer apparatus and method of use thereof

The invention comprises a method and apparatus for sampling a common tissue volume and/or a common skin layer skin of a person as a part of noninvasive analyte property determination system, comprising the steps of: providing an analyzer, comprising at least three detectors at least partially embedded in a probe housing, the probe housing comprising a sample side surface, the detectors including a first and second range of detection zones of differing radial distances from a first illumination zone and second illumination zone, respectively coupled to separate sources; repetitively illuminating the illumination zones of the skin with photons in a range of 1200 to 2500 nm; and detecting portions of light from the sources with the at least three detectors, the detectors positioned on a common line with the sources.

Common sample zone noninvasive glucose concentration determination analyzer apparatus and method of use thereof

The invention comprises a method and apparatus for noninvasively determining state of a person, comprising the steps of: providing an analyzer comprising a first and second spectrometer unit and a main controller subsystem; replaceably attaching the first spectrometer unit to the person at a first illumination zone; the first spectrometer unit delivering first photons, from first illumination optics, along a first mean z-axis optical path normal to a first x/y-plane tangentially contacting the first illumination zone of the person; replaceably attaching a second spectrometer unit to the person at a second illumination zone; the second spectrometer delivering second photons, from second illumination optics, along a second mean z-axis optical path perpendicular to a second x/y-plane tangentially contacting the second illumination zone of the skin, the first x/y-plane noncoplanar with the second x/y-plane; and the main controller processing detected signals to generate at least one measure of state of the person.

Multiple sensor glucose concentration determination analyzer apparatus and method of use thereof

The invention comprises a method for noninvasively determining a sample property, comprising controlling photon generation from a source and analyzing signal from a set of detectors; irradiating an illumination zone of skin with the photons; and detecting diffusely reflected photons from the skin, the set of detectors respectively optically coupled to a set of detection zones of the skin positioned along a spiral path between a first and second radial distance from the illumination zone, where a first detection zone of a first detector of the set of detectors extends radially outward from the illumination zone to at least an inward radial distance, from the illumination zone, of a second detection zone of a second detector of the set of detectors, where at least one detection zone of the set of detection zones has a central radial distance from the illumination zone between the first and second radial distances.

Depth resolved noninvasive glucose concentration determination analyzer apparatus and method of use thereof

The invention comprises a method and apparatus for selecting optical pathways sampling a common tissue layer, such as the dermis, of a person for analysis in a noninvasive analyte property determination systemy, comprising the steps of: probing skin with a range of illumination zone-to-detection zone distances with at least two wavelength ranges, which optionally overlap, and selecting, using a metric, illumination zone-to-detection zone distances having mean optical pathways probing the common tissue layer, such as without the mean optical pathways entering the subcutaneous fat layer of the person. Optionally, the skin tissue layers are modulated and/or treated via tissue displacement before and/or during data collection.

Sample depth resolved noninvasive glucose concentration determination analyzer apparatus and method of use thereof

The invention comprises a method and apparatus for sampling optical pathways having a common tissue depth, such as a maximum mean depth of penetration in the dermis, with a common detector of a person for analysis in a noninvasive analyte property determination system, comprising the steps of: probing skin with a range of illumination zone-to-detection zone distances with at least two wavelength ranges, which optionally overlap, and detecting, using a common detector, illumination zone-to-detection zone distances having mean optical pathways probing the common tissue layer, such as without the mean optical pathways entering the subcutaneous fat layer of the person. Optionally, the skin tissue layers are modulated and/or treated via tissue displacement before and/or during data collection.

Common depth noninvasive glucose concentration determination analyzer apparatus and method of use thereof

The invention relates generally to a probe interface method and apparatus for use in conjunction with an optical based noninvasive analyzer. More particularly, an algorithm controls a sample probe position and attitude relative to a skin sample site before and/or during sampling. For example, a sample probe head of a sample module is controlled by an algorithm along the normal-to-skin-axis. Preferably, the sample probe head is positioned in terms of 3-D location in the x-, y-, and z-axes and is attitude orientated in terms of pitch, yaw, and roll. Further, attitude of the probe head is preferably orientated prior to contact of the sample probe head with the tissue sample using indicators, such as non-contact distance feedback from capacitance sensor, contacting or non-contacting optical sensors, and/or contact electrical sensors.

Method and apparatus for controlling positioning of a noninvasive analyzer sample probe

Sampling is controlled in order to enhance analyte concentration estimation derived from noninvasive sampling. More particularly, sampling is controlled using controlled fluid delivery to a region between a tip of a sample probe and a tissue measurement site. The controlled fluid delivery enhances coverage of a skin sample site with the thin layer of fluid. Delivery of contact fluid is controlled in terms of spatial delivery, volume, thickness, distribution, temperature, and/or pressure.

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Mesa, AZ, United States of America

Christopher Slawinski