Soligenix, Inc.

Christopher Schaber

Rasappa Gounder Arumugham

Holger Rauter

Silvia Werner

Robert N Brey

George B McDonald

George B Mcdonald

Rasappa Arumugham

Improved systems and methods for producing synthetic hypericin at high volume and high purity. In particular, systems and methods of preparing a purified synthetic hypericin resulting from irradiation, wherein the irradiation step is performed in a continuous flow micro-reactor. The process of manufacturing purified synthetic hypericin results in the synthetic yield of 30-100% of the dry product.

Systems and methods for producing synthetic hypericin

Stable immunogenic composition capable of eliciting a robust and durable immune response yielding a measurable increase in neutralizing antibodies at least 200 days post-administration, comprising at least one antigen consisting of a ribosome inactivating protein and at least one antigen comprising a toxin derived from bacterial spores. Method making and using a stable immunogenic composition capable of eliciting a stable immune response yielding a measurable increase in neutralizing antibodies at least 200 days post-administration, comprising providing an immunogenic composition comprising at least one antigen comprising a ribosome inactivating protein and at least one antigen comprising a toxin derived from bacterial spores and administering the immunogenic composition to an individual.

Multivalent stable vaccine composition and methods of making same

Improved systems and methods for producing synthetic hypericin at high volume and high purity.

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Princeton, NJ, United States of America

Christopher Schaber